Extended References

Facilitated Transport of Glucose and Water

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Deng, D., et al. 2014. Crystal structure of the human glucose transporter GLUT1. Nature 510:121–126.

Gonen, T., and T. Walz. 2006. The structure of aquaporins. Quart. Rev. Biophys. 39:361–396.

King, L. S., D. Kozono, and P. Agre. 2004. From structure to disease: the evolving tale of aquaporin biology. Nat. Rev. Mol. Cell Biol. 5:687–698.

Thorens, B., and M. Mueckler. 2010. Glucose transporters in the 21st century. Am. J. Physiol.-Endoc. M. 298:E141–E145.

ATP-Powered Pumps and the Intracellular Ionic Environment

Aller, S., et al. 2009. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 323:1718–1722.

Brini, M., et al. 2013. The plasma membrane calcium pump in health and disease. FEBS J. 280:5385–5397.

Gottesman, M. M., and V. Ling. 2006. The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett. 580:998–1009.

Grewer, C., et al. 2013. Electrophysiological characterization of membrane transport proteins. Annu. Rev. Biophys. 42:95–120.

Guerini, D., L. Coletto, and E. Carafoli. 2005. Exporting calcium from cells. Cell Calcium 38:281–289.

Guttmann, D., et al. 2009. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1. Trends Biochem. Sci. 35:36–42.

Ogawa, H., et. al. 2009. Crystal structure of the sodium-potassium pump (Na+, K+-ATPase) with bound potassium and ouabain. P. Natl Acad. Sci. USA 106:13742–13747.

Oldham, M. L., A. L. Davidson, and J. Chen. 2008. Structural insights into ABC transporter mechanism. Curr. Opin. Struc. Biol. 18:726–733.

Penmatsa, A., and E. Gouaux. 2014. How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. J. Physiol. 592:863–869.

Raggers, R. J., et al. 2000. Lipid traffic: the ABC of transbilayer movement. Traffic 1:226–234.

Ramsey B. W., et al. 2011. A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N. Engl. J. Med. 365:1663–1672.

Riordan, J. 2005. Assembly of functional CFTR chloride channels. Annu. Rev. Physiol. 67:701–718.

Shinoda, T., et. al. 2009. Crystal structure of the sodium–potassium pump at 2.4 Å resolution. Nature 459:446–450.

Toel, M., R. Saum, and M. Forgac. 2010. Regulation and isoform function of the V-ATPases. Biochemistry 49:4715–4723.

Toyoshima, C. 2009. How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane. Biochim. Biophys. Acta 1793:941–946.

Nongated Ion Channels and the Resting Membrane Potential

Dudev, T., and C. Lin. 2014. Ion selectivity strategies of sodium channel selectivity filters. Accounts Chem. Res. 47:3580–3587.

Dutzler, R., et al. 2002. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415:287–294.

Gouaux, E., and R. Mackinnon. 2005. Principles of selective ion transport in channels and pumps. Science 310:1461–1465.

Hibino, H., et al. 2010. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol. Rev. 90:291–366.

Hille, B. 2001. Ion Channels of Excitable Membranes, 3d ed. Sinauer Associates.

Jentsch, T. J. 2008. ClC chloride channels and transporters: from genes to protein structure, pathology and physiology. Crit. Rev. Biochem. Mol. 43:3–36.

MacKinnon, R. 2004. Potassium channels and the atomic basis of selective ion conduction. Nobel Lecture reprinted in Bioscience Rep. 24:75–100.

Neher, E. 1992. Ion channels for communication between and within cells. Nobel Lecture reprinted in Neuron 8:605–612 and Science 256:498–502.

Neher, E., and B. Sakmann. 1992. The patch clamp technique. Sci. Am. 266(3):28–35.

Planells-Cases, R., and T. J. Jentsch. 2009. Chloride channelopathies. Biochim. Biophys. Acta 1792:173–189.

Roux, B. 2005. Ion conduction and selectivity in K+ channels. 2005. Annu. Rev. Bioph. Biom. 34:153–171.

Zhou, Y., et al. 2001. Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2 Å resolution. Nature 414:43–48.

Cotransport by Symporters and Antiporters

Alper, S. L. 2009. Molecular physiology and genetics of Na+-independent SLC4 anion exchangers. J. Exp. Biol. 212:1672–1683.

Diallinas, G. 2008. An almost-complete movie: structural snapshots of transporter proteins reveal how they transport species across membranes. Science 322:1644–1645.

Gao, X., et al. 2009. Structure and mechanism of an amino acid antiporter. Science 324:1565–1568.

Gouaux, E. 2009. Review: The molecular logic of sodium-coupled neurotransmitter transporters. Phil. Trans. R. Soc. Lond. B Biol. Sci. 364:149–154.

Krishnamurthy, H., C. L. Piscitelli, and E. Gouaux. 2009. Unlocking the molecular secrets of sodium-coupled transporters. Nature 459:347–355.

Orlowski, J., and S. Grinstein. 2007. Emerging roles of alkali cation/proton exchangers in organellar homeostasis. Curr. Opin. Cell Biol. 19:483–492.

Shabala, S., and T. A. Cuin. 2008. Potassium transport and plant salt tolerance. Physiol. Plant 133:651–669.

Wright, E. M. 2004. The sodium/glucose cotransport family SLC5. Pflug. Arch. 447:510–518.

Wright, E. M., and D. D. Loo. 2000. Coupling between Na+, sugar, and water transport across the intestine. A. NY Acad. Sci. 915:54–66.

Transcellular Transport

Anderson, J. M., and C. M. Van Itallie. 2009. Physiology and function of the tight junction. Cold Spring Harb. Perspect. Biol. 1:a002584.

Elkouby-Naor, L., and T. Ben-Yosef. 2010. Functions of claudin tight junction proteins and their complex interactions in various physiological systems. Int. Rev. Cell Mol. Biol. 279:1–32.

Hubner, C. A., and T. J. Jentsch. 2008. Channelopathies of transepithelial transport and vesicular function. Adv. Genet. 63:113–152.

Rao, M. 2004. Oral rehydration therapy: new explanations for an old remedy. Annu. Rev. Physiol. 66:385–417.

Schafer, J. A. 2004. Renal water reabsorption: a physiologic retrospective in a molecular era. Kidney Int. Suppl. 91:S20–27.

Schultz, S. G. 2001. Epithelial water absorption: osmosis or cotransport? P. Natl. Acad. Sci. USA 98:3628–3630.

Sobacchi, C., et al. 2013. Osteopetrosis: genetics, treatment and new insights into osteoclast function. Nat. Rev. Endocrinol. 9:522–536.

New Perspectives

Liao, M., et al. 2014. Single particle electron cryo-microscopy of a mammalian ion channel. Curr. Opin. Struc. Biol. 27:1–7.

Stansfeld, P. J. and M. S. P. Sansom. 2011. Molecular simulation approaches to membrane proteins. Structure 19:1562–1572.

Wisedchaisri, G., S. L. Reichow, and T. Gonen. 2011. Advances in structural and functional analysis of membrane proteins by electron crystallography. Structure 19:1381–1393.