Targeting Proteins To and Across the ER Membrane

Egea, P. F., R. M. Stroud, and P. Walter. 2005. Targeting proteins to membranes: structure of the signal recognition particle. Curr. Opin. Struct. Biol. 15:213–220.

Osborne, A. R., T. A. Rapoport, and B. van den Berg. 2005. Protein translocation by the Sec61/SecY channel. Annu. Rev. Cell Dev. Biol. 21:529–550.

Wickner, W., and R. Schekman. 2005. Protein translocation across biological membranes. Science 310:1452–1456.

Insertion of Membrane Proteins into the ER

Englund, P. T. 1993. The structure and biosynthesis of glycosylphosphatidylinositol protein anchors. Annu. Rev. Biochem. 62:121–138.

Mothes, W., et al. 1997. Molecular mechanism of membrane protein integration into the endoplasmic reticulum. Cell 89:523–533.

Shao, S., and R. S. Hegde. 2011. Membrane protein insertion at the endoplasmic reticulum. Annu. Rev. Cell Dev. Biol. 27:25–56.

Wang, F., et al. 2011. The mechanism of tail-anchored protein insertion into the ER membrane. Mol. Cell 43:738–750.

Protein Modifications, Folding, and Quality Control in the ER

Braakman, I., and N. J. Bulleid. 2011. Protein folding and modification in the mammalian endoplasmic reticulum. Annu. Rev. Biochem. 80:71–99.

Hegde, R. S., and H. L. Ploegh. 2010. Quality and quantity control at the endoplasmic reticulum. Curr. Opin. Cell Biol. 22:437–446.

Helenius, A., and M. Aebi. 2004. Roles of N-linked glycans in the endoplasmic reticulum. Annu. Rev. Biochem. 73:1019–1049.

Kornfeld, R., and S. Kornfeld. 1985. Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 45:631–664.

Patil, C., and P. Walter. 2001. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 13:349–355.

Sevier, C. S., and C. A. Kaiser. 2002. Formation and transfer of disulphide bonds in living cells. Nat. Rev. Mol. Cell Biol. 3:836–847.

Smith, M. H., H. L. Ploegh, and J. S. Weissman. 2011. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science 334:1086–1090.

630

Targeting of Proteins to Mitochondria and Chloroplasts

Dalbey, R. E., and A. Kuhn. 2000. Evolutionarily related insertion pathways of bacterial, mitochondrial, and thylakoid membrane proteins. Annu. Rev. Cell Dev. Biol. 16:51–87.

Dolezal, P., et al. 2006. Evolution of the molecular machines for protein import into mitochondria. Science 313:314–318.

Koehler, C. M. 2004. New developments in mitochondrial assembly. Annu. Rev. Cell Dev. Biol. 20:309–335.

Li, H.-M., and C.-C. Chiu. 2010. Protein transport into chloroplasts. Ann. Rev. Plant Biol. 61:157–180.

Matouschek, A., N. Pfanner, and W. Voos. 2000. Protein unfolding by mitochondria: the Hsp70 import motor. EMBO Rep. 1:404–410.

Neupert, W., and M. Brunner. 2002. The protein import motor of mitochondria. Nat. Rev. Mol. Cell Biol. 3:555–565.

Robinson, C., and A. Bolhuis. 2001. Protein targeting by the twin-arginine translocation pathway. Nat. Rev. Mol. Cell Biol. 2:350–356.

Schmidt, O., N. Pfanner, and C. Meisinger. 2010. Mitochondrial protein import: from proteomics to functional mechanisms. Nat. Rev. Mol. Cell Biol. 11:655–667.

Targeting of Peroxisomal Proteins

Dammai, V., and S. Subramani. 2001. The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell 105:187–196.

Gould, S. J., and D. Valle. 2000. Peroxisome biogenesis disorders: genetics and cell biology. Trends Genet. 16:340–345.

Hoepfner, D., et al. 2005. Contribution of the endoplasmic reticulum to peroxisome formation. Cell 122:85–95.

Ma, C., G. Agrawal, and S. Subramani. 2011. Peroxisome assembly: matrix and membrane protein biogenesis. J. Cell Biol. 193:7–16.

Purdue, P. E., and P. B. Lazarow. 2001. Peroxisome biogenesis. Annu. Rev. Cell Dev. Biol. 17:701–752.

Smith, J. J., and J. D. Aitchison. 2013. Peroxisomes take shape. Nat. Rev. Mol. Cell Biol. 14:803–817.

Transport Into and Out of the Nucleus

Chook, Y. M., and G. Blobel. 2001. Karyopherins and nuclear import. Curr. Opin. Struct. Biol. 11:703–715.

Cole, C. N., and J. J. Scarcelli. 2006. Transport of messenger RNA from the nucleus to the cytoplasm. Curr. Opin. Cell Biol. 18:299–306.

Johnson, A. W., E. Lund, and J. Dahlberg. 2002. Nuclear export of ribosomal subunits. Trends Biochem. Sci. 27:580–585.

Ribbeck, K., and D. Gorlich. 2001. Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 20:1320–1330.

Rout, M. P., and J. D. Aitchison. 2001. The nuclear pore complex as a transport machine. J. Biol. Chem. 276:16593–16596.

Schwartz, T. U. 2005. Modularity within the architecture of the nuclear pore complex. Curr. Opin. Struct. Biol. 15:221–226.

Stewart, M. 2010. Nuclear export of mRNA. Trends Biochem. Sci. 35:609–617.

Terry, L. J., and S. R. Wente. 2009. Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport. Eukaryot. Cell 8:1814–1827.