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Studying Cell-Surface Receptors and Signal Transduction Proteins

Flock, T., et al. 2015. Universal allosteric mechanism for G_α activation by GPCRs. Nature, doi:10.1038/nature14663.

Garland, S. 2013. Are GPCRs still a source of new targets? J. Biomol. Screen. 18:947–966.

Grecco, H., M. Schmick, and P. Bastiaens. 2011. Signaling from the living plasma membrane. Cell 144:897–909.

Gross, A., and H. F. Lodish. 2006. Cellular trafficking and degradation of erythropoietin and NESP. J. Biol. Chem. 281:2024–2032.

Scott, J. D., et al., 2013. Creating order from chaos: cellular regulation by kinase anchoring. Annu. Rev. Pharmacol. 53:187–210.

Taylor, S. S., and A. Kornev. 2011. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem. Sci. 36:65–77.

G Protein–Coupled Receptors: Structure and Mechanism

Audel, M., and M. Bouvier. 2012. Restructuring G-protein-coupled receptor activation. Cell 151:14–23.

Benovic, J. 2012. G-protein-coupled receptors signal victory. Cell 151:1–3. (A review of the research leading to the 2011 Nobel Prize.)

Irannejad, R., et al. 2013. Conformational biosensors reveal GPCR signalling from endosomes. Nature 495:534–538.

Tesmer, J. 2010. The quest to understand heterotrimeric G protein signalling. Nat. Struct. Mol. Biol. 17:650–652.

G Protein–Coupled Receptors That Regulate Ion Channels

Calvert, P., et al. 2006. Light-driven translocation of signaling proteins in vertebrate photoreceptors. Trends Cell Biol. 16:560–568.

Hofmann, K. P., et al. 2009. A G protein-coupled receptor at work: the rhodopsin model. Trends Biochem. Sci. 34:540–552.

Pearring, J. N. 2013. Protein sorting, targeting and trafficking in photoreceptor cells. Prog. Retin. Eye Res. 36:24–61.

Smith, S. O. 2010. Structure and activation of the visual pigment rhodopsin. Annu. Rev. Biophys. 39:309–328.

G Protein–Coupled Receptors That Activate or Inhibit Adenylyl Cyclase

Agius, L. 2010. Physiological control of liver glycogen metabolism: lessons from novel glycogen phosphorylase inhibitors. Mini-Rev. Med. Chem. 10:1175–1187.

DeWire, S., et al. 2007. β-Arrestins and cell signaling. Annu. Rev. Physiol. 69:483–510.

Lefkowitz, R. J., and S. K. Shenoy. 2005. Transduction of receptor signals by β-arrestins. Science 308:512–517.

Shula, A., et al. 2014. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature 512:218–222.

Somsak, L., et al. 2008. New inhibitors of glycogen phosphorylase as potential antidiabetic agents. Curr. Med. Chem. 15:2933–2983.

Taylor, S. S., et al. 2012. Assembly of allosteric macromolecular switches: lessons from PKA. Nat. Rev. Mol. Cell Biol. 13:646–658.

G Protein–Coupled Receptors That Trigger Elevations in Cytosolic and Mitochondrial Calcium

Hoflich, K. P., and M. Ikura. 2002. Calmodulin in action: diversity in target recognition and activation mechanisms. Cell 108:739–742.

Hogan, P. G., R. S. Lewis, and A. Rao. 2010. Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu. Rev. Immunol. 28:491–533.

Kaufman, R., and J. Amphora. 2014. Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochim. Biophys. Acta 1843:2233–2239.

Parekh, A. 2011. Decoding cytosolic Ca²⁺ oscillations. Trends Biochem. Sci. 36:78–87.

Soboloff, J., et al. 2012. STIM proteins: dynamic calcium signal transducers. Nat. Rev. Mol. Cell Biol. 13:549–565.

Zhou, Y., et al. 2010. Pore architecture of the ORAI1 store-operated calcium channel. P. Natl Acad. Sci. USA 107:4896–4901.