References

Early Mammalian Development and Embryonic Stem Cells

Ben-David, U., J. Nissenbaum, and N. Benvenisty. 2013. New balance in pluripotency: reprogramming with lineage specifiers. Cell 153:939–940.

Graf, T., and T. Enver. 2009. Forcing cells to change lineages. Nature 462:587–594.

Hanna, J., K. Saha, and R. Jaenisch. 2010. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 143:508–525.

Mallanna, S., and A. Rizzino. 2010. Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Dev. Biol. 344:16–25.

McNeish, J., et al. 2015. From dish to bedside: lessons learned while translating findings from a stem cell model of disease to a clinical trial. Cell Stem Cell 17:8–10.

Orkin, S., and K. Hochedlinger. 2011. Chromatin connections to pluripotency and cellular reprogramming. Cell 145:835–850.

Pagliuca, F., et al. 2014. Generation of functional human pancreatic β cells in vitro. Cell 159:428–439.

1024

Robinton, D., and G. Daley. 2014. The promise of induced pluripotent stem cells in research and therapy. Nature 481:295–305.

Surface, L., S. Thornton, and L. Boyer. 2010. Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 7:288–298.

Theunissen, T., and R. Jaenisch. 2014. Molecular control of induced pluripotency. Cell Stem Cell 14:720–734.

Young, R. 2011. Control of the embryonic stem cell state. Cell 144:940–954.

Stem Cells and Niches in Multicellular Organisms

Aichinger, E., et al. 2012. Plant stem cell niches. Annu. Rev. Plant Biol. 63:615–636.

Blanpain, C., and E. Fuchs. 2014. Plasticity of epithelial stem cells in tissue regeneration. Science 344:1243.

Clevers, H., et al. 2014. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 346:1248012.

Goodell, M., H. Nguyen, and N. Shroyer. 2015. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat. Rev. Mol. Cell Biol. 16:299–309.

He, S., D. Nakada, and S. Morrison. 2009. Mechanisms of stem cell self-renewal. Annu. Rev. Cell Dev. Biol. 25:377–406.

Heidstra, R., and S. Sabatini. 2014. Plant and animal stem cells: similar yet different. Nat. Rev. Mol. Cell Biol. 15:301–312.

Morrison, S. J., and J. Kimble. 2006. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441:1068–1074.

Suh, H., W. Deng, and P. Gage. 2009. Signaling in adult neurogenesis. Annu. Rev. Cell Dev. Biol. 25:253–275.

Tanaka, E., and P. Reddien. 2011. The cellular basis for animal regeneration. Dev. Cell 21:172–185.

Zhang, C., and H. Lodish. 2008. Cytokine regulation of hematopoietic stem cell function. Curr. Opin. Hematol. 15:307–311.

Mechanisms of Cell Polarity and Asymmetric Cell Division

Cabernard, C., and C. Q. Doe. 2009. Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila. Dev. Cell 17:134–141.

Devenport, D. 2014. The cell biology of planar cell polarity. J. Cell Biol. 207:171–179.

Knoblich, J. A. 2008. Mechanisms of asymmetric stem cell division. Cell 132:583–597.

Li, R., and B. Bowerman, eds. 2010. Symmetry Breaking in Biology. Cold Spring Harbor Laboratory Press.

Mellman, I., and W. J. Nelson. 2008. Coordinated protein sorting, targeting and distribution in polarized cells. Nat. Rev. Mol. Cell Biol. 9:833–845.

Nelson, W. J. 2003. Adaption of core mechanisms to generate cell polarity. Nature 422:766–774.

Ragkousi, K., and M. C. Gibson. 2014. Cell division and the maintenance of epithelial order. J. Cell Biol. 207:181–188.

Shivas, J. M., et al. 2010. Polarity and endocytosis: reciprocal regulation. Trends Cell Biol. 20:445–452.

Siller, K. H., and C. Q. Doe. 2009. Spindle orientation during asymmetric cell division. Nat. Cell Biol. 11:365–374.

St. Johnston, D., and J. Ahringer. 2010. Cell polarity in eggs and epithelia: parallels and diversity. Cell 141:757–774.

Zallen, J. A. 2007. Planar polarity and tissue morphogenesis. Cell 129:1051–1063.

Cell Death and Its Regulation

Adams, J. M., and S. Cory. 2007. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr. Opin. Immunol. 19:488–496.

Ashkenazi, A., and G. Salvesen. 2014. Regulated cell death: signaling and mechanisms. Annu. Rev. Cell Dev. Biol. 30:337–356.

Bouillet, P., and L. A. O’Reilly. 2009. CD95, BIM and T cell homeostasis. Nat. Rev. Immunol. 9:514–519.

Christofferson, D., Y. Li, and J. Yuan. 2014 Control of life-or-death decisions by RIP1 kinase. Annu. Rev. Physiol. 76:129–50.

Giam, M., D. C. Huang, and P. Bouillet. 2008. BH3-only proteins and their roles in programmed cell death. Oncogene 27(suppl. 1):S128–S136.

Hay, B. A., and M. Guo. 2006. Caspase-dependent cell death in Drosophila. Annu. Rev. Cell Dev. Biol. 22:623–650.

Riedl, S. J., and G. Salvesen. 2007. The apoptosome: signalling platform of cell death. Nat. Rev. Mol. Cell Biol. 8:405–413.

Ryoo, H. D., and E. H. Baehrecke. 2010. Distinct death mechanisms in Drosophila development. Curr. Opin. Cell Biol. 22:889–895.

Teng, X., and J. Hardwick. 2010. The apoptosome at high resolution. Cell 141:402–404.