Introduction

Weinberg, R. A. 2006. The Biology of Cancer. Garland Science.

How Tumor Cells Differ From Normal Cells

De Bock, K., M. Mazzone, and P. Carmeliet. 2011. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat. Rev. Clin. Oncol. 8(7):393–404.

Desgrosellier, J. S., and D. A. Cheresh. 2010. Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 10(1):9–22.

1170

Giancotti, F. G. 2013. Mechanisms governing metastatic dormancy and reactivation. Cell 155(4):750–764.

Grivennikov, S. I., F. R Greten, and M. Karin. 2010. Immunity, inflammation, and cancer. Cell 140(6):883–899.

Hanahan, D., and R. A. Weinberg. 2011. Hallmarks of cancer: the next generation. Cell 144:646–674.

Joyce, J. A., and J. W. Pollard. 2009. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9(4):239–252.

Korbel, J. O., and P. J. Campbell. 2013. Criteria for inference of chromothripsis in cancer genomes. Cell 152(6):1226–1236.

Nguyen, D. X., P. D. Bos, and J. Massagué. 2009. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9(4):274–284.

Pfau, S. J., and A. Amon. 2012. Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep. 13(6):515–527.

Sethi, N., and Y. Kang. 2011. Unravelling the complexity of metastasis—molecular understanding and targeted therapies. Nat. Rev. Cancer 11(10):735–748.

Thiery, J. P., et al. 2009. Epithelial-mesenchymal transitions in development and disease. Cell 139(5):871–890.

Vander Heiden, M. G., L. C. Cantley, and C. B. Thompson. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930):1029–1033.

The Origins and Development of Cancer

Heyer, J., et al. 2010. Non-germline genetically engineered mouse models for translational cancer research. Nat. Rev. Cancer 10:470–480.

Khaled, W. T., and P. Liu. 2014. Cancer mouse models: past, present and future. Semin. Cell Dev. Biol. 27:54–60.

Kinzler, K. W., and B. Vogelstein. 1996. Lessons from hereditary colorectal cancer. Cell 87:159–170.

Loechler, E. L. 2002. Environmental carcinogens and mutagens. In Encyclopedia of Life Sciences. Nature Publishing.

Wogan, G. N., et al. 2004. Environmental and chemical carcinogenesis. Semin. Cancer Biol. 14:473–486.

The Genetic Basis of Cancer

Dawson, M. A., and T. Kouzarides. 2012. Cancer epigenetics: from mechanism to therapy. Cell 150(1):12–27.

Garraway, L. A., and E. S. Lander. 2013. Lessons from the cancer genome. Cell 153(1):17–37.

Grisendi, S., and P. P. Pandolfi. 2005. Two decades of cancer genetics: from specificity to pleiotropic networks. Cold Spring Harb. Symp. Quant. Biol. 70:83–91.

Lujambio, A., and S. W. Lowe. 2012. The microcosmos of cancer. Nature 482(7385):347–355.

Morrow, P. K., and G. N. Hortobagyi. 2009. Management of breast cancer in the genome era. Annu. Rev. Med. 60:153–165.

Sellers, W. R. 2011. A blueprint for advancing genetics-based cancer therapy. Cell 147(1):26–31.

Vogelstein, B., et al. 2013. Cancer genome landscapes. Science 339:1546–1558. doi: 10.1126/science.1235122.

Misregulation of Cell Growth and Death Pathways in Cancer

Cotter, T. G. 2009. Apoptosis and cancer: the genesis of a research field. Nat. Rev. Cancer 9(7):501–507.

Dang, C. V. 2012. MYC on the path to cancer. Cell 149(1):22–35.

Holderfield, M., et al. 2014. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat. Rev. Cancer 14(7):455–467.

Jiang, J., and C. Hui. 2008. Hedgehog signaling in development and cancer. Dev. Cell 15(6):801–812.

Pickup, M., S. Novitskiy, and H. L. Moses. 2013. The roles of TGFβ in the tumour microenvironment. Nat. Rev. Cancer 13(11):788–799.

Pylayeva-Gupta, Y., E. Grabocka, and D. Bar-Sagi. 2011. RAS oncogenes: weaving a tumorigenic web. Nat. Rev. Cancer 11(11):761–774.

Shaulian, E., and M. Karin. 2002. AP-1 as a regulator of cell life and death. Nature Cell Biol. 4:E131–E136.

Shaw, A. T., et al. 2013. Tyrosine kinase gene rearrangements in epithelial malignancies. Nat. Rev. Cancer 13(11):772–787.

Deregulation of the Cell Cycle and Genome Maintenance Pathways in Cancer

Bieging, K. T., S. S. Mello, and L. D. Attardi. 2014. Unravelling mechanisms of p53-mediated tumour suppression. Nat. Rev. Cancer 14(5):359–370.

Bunting, S. F., and A. Nussenzweig. 2013. End-joining, translocations and cancer. Nat. Rev. Cancer 13(7):443–454.

Burkhart, D. L., and J. Sage. 2008. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 8(9):671–682.

Curtin, N. J. 2012. DNA repair dysregulation from cancer driver to therapeutic target. Nat. Rev. Cancer 12(12):801–817.

Daley, J. M., and P. Sung. 2014. 53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks. Mol. Cell Biol. 34(8):1380–1388.

Jiricny, J. 2006. The multifaceted mismatch-repair system. Nature Rev. Mol. Cell Biol. 7:335–346.

Malumbres, M., and M. Barbacid. 2001. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1:222–231.

Manning, A. L., and N. J. Dyson. 2012. RB: mitotic implications of a tumour suppressor. Nat. Rev. Cancer 12(3):220–226.

Moody, C. A., and L. A. Laimins. 2010. Human papillomavirus oncoproteins: pathways to transformation. Nat. Rev. Cancer 10(8):550–560.