Chapter 24. Analyzing Cervical Cancer Through Mouse Models
Introduction
Analyze the Data
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Analyze the Data 24-2: Analyzing Cervical Cancer Through Mouse Models
The E7 oncoprotein of the high-risk human papillomaviruses (HPV) is thought to contribute to cervical carcinogenesis at least in part by disrupting regulation of the cell cycle in cervical epithelial cells. E7 can misregulate the cell cycle through its interaction with several cellular proteins, including the retinoblastoma suppressor protein RB as well as the cyclin-dependent kinase inhibitor p21Cip1.
a. How can transgenic mouse models be used to assess the effect of p21 on cell cycle misregulation?
_feedback: Transgenic models can be utilized to either enhance p21 (+/+) mice or eliminate p21 (–/–) expression of certain proteins. Mutant viral proteins, including E7, can be expressed in transgenic mouse models to isolate the function of these proteins from that of normal cellular proteins. This can help to establish causal relationships between the mutations and alterations in normal cellular phenotypes, including oncogenesis.
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