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Telomere Replication

Chapter 8. Telomere Replication

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Animation Activity: 8-44: Telomere Replication

1.

Telomerase is a type of:

DNA polymerase.

RNA polymerase.

primer.

reverse transcriptase.

ligase.

Correct.

Incorrect.

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2.

Why is the lagging strand of a telomere shortened by a few bases after each cycle of replication?

because DNA polymerase only synthesizes DNA from the 3’ end

because DNA polymerase only synthesizes DNA from the 5’ end

because DNA polymerase cannot function in the presence of the RNA primer located on the lagging strand

because the DNA replication machinery only recognizes DNA primers, rather than RNA primers

because the appropriate template for the DNA polymerase is lacking

Correct.

Incorrect.

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3.

Telomerase uses a ________ template and synthesizes in the ________ direction to extend the length of the ________ strand of the telomere DNA.

DNA; 5’ to 3’; lagging

RNA; 5’ to 3’; lagging

DNA; 3’ to 5’; leading

RNA; 3’ to 5’; lagging

RNA; 5’ to 3’; leading

Correct.

Incorrect.

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4.

If a cell lacks the telomerase enzyme, what would be expected?

The RNA primer would remain bound to the lagging strand and become part of the telomere.

The entire telomere would degrade because the leading strand would always be longer than the lagging strand.

The telomere lagging strand would shorten by a few bases with each round of replication.

There would be no major effect because an additional enzyme can be recruited to the telomere to synthesize DNA in the 3’ to 5’ direction if necessary.

All of the above would be expected.

Correct.

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5.

Why do you speculate that telomerase is important to the cell?

It maintains the length of telomeres, which acts as caps for chromosomes, maintaining chromosomal integrity.

Continual shortening of chromosomes will eventually damage critical DNA regions, such as genes.

It can act in the place of DNA polymerase, which is important in cells with mutated DNA polymerase.

Both A and B are correct.

All of the above are correct.

Correct.

Incorrect.

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Chapter 8. Telomere Replication

Introduction

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