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Eukaryotic Transcriptional Control

Chapter 9. Eukaryotic Transcriptional Control

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Animation Activity: 9-3: Eukaryotic Transcriptional Control

1.

Which is NOT involved in transcriptional initiation?

chromatin decondensation

acetylation of histones

DSIF

mediator complex

TATA box

Correct.

Incorrect.

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2.

Which is considered a negative regulator of transcription?

NELF

P-TEFb

TFIIH

5’ cap

All of the above.

Correct.

Incorrect.

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3.

Phosphorylation of the CTD of RNA polymerase is necessary for all of the following EXCEPT:

allowing detachment of RNA polymerase from the initiation factors.

preventing chromatin condensation.

allowing transcriptional elongation to proceed.

providing a docking site for enzymes that modify the RNA being transcribed.

All of the above require phosphorylation of the CTD.

Correct.

Incorrect.

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4.

Place the following steps of transcriptional activation in the correct order:
I. Binding of the mediator complex to the DNA
II. Acetylation of histones
III. Formation of the transcription bubble
IV. Recruitment of pioneer transcription factors
V. Phosphorylation of the CTD of RNA polymerase

I, III, V, IV, II

II, III, I, IV, V

IV, II, I, III, V

II, IV, III, I, V

II, I, IV, V, III

Correct.

Incorrect.

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5.

A dysfunctional P-TEFb protein that has lost its kinase ability is expressed in a eukaryotic cell. Which could be expected to occur?

NELF remains bound to the DNA.

DSIF is unable to keep RNA polymerase clamped onto the DNA.

Transcriptional elongation no longer proceeds.

NELF remains bound to DSIF.

All of the above could occur.

Correct.

Incorrect.

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Chapter 9. Eukaryotic Transcriptional Control

Introduction

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