Chapter 10. RNA Splicing

Animation Activities

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Animation Activity: 10-11: RNA Splicing

1.

The spliceosome consists of:

snRNPs.

snRNAs.

U1.

U4.

All of the above are correct.

Correct.

Incorrect.

Try Again.

2.

The branch point A does not participate in base pairing with the ________ to allow for the first ________ reaction in RNA splicing via the ________ group of the branch point A.

U1 snRNA; polymerization; 3’ OH

3’ splice site; debranching; 5’ PO4

3’ splice site; transesterification; 3’ OH

U2 snRNA; transesterification; 2’ OH

U2 snRNA; debranching; 2’ OH

Correct.

Incorrect.

Try Again.

3.

Place the following events of RNA splicing in the correct sequence:
I. Formation of a 2’ 5’ phosphodiester bond between the branch point and 5’ end of the intron
II. The first transesterification reaction, catalyzed by U2 and U6
III. Recruitment of U3, U4, and U5 to the preRNA
IV. Binding of SF1 to the branch point A
V. Joining of the two exons via a 3’ 5’ phosphodiester bond

IV, III, II, I, V

III, IV, II, I, V

IV, III, I, II, V

III, IV, II, V, I

II, IV, III, I, V

Correct.

Incorrect.

Try Again.

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Chapter 10. RNA Splicing

Introduction

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