Chapter 11. The Plasma-Membrane Na⁺/K⁺ ATPase

Animation Activities

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Animation Activity 11-13: The Plasma-Membrane Na⁺/K⁺ ATPase

1.

The Na⁺/K⁺ ATPase acts via _______ to move ions against their concentration gradients, thus requiring _______.

active transport; ATP

passive transport; ATP

diffusion; an established concentration gradient

active transport; Na⁺ and K⁺ ions

passive transport; Na⁺ and K⁺ ions

Correct.

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2.

For each molecule of ATP hydrolyzed by the Na⁺/K⁺ ATPase:

3 Na⁺ and 2 K⁺ are pumped out of the cell against their concentration gradients.

3 Na⁺ are pumped into the cell, and 2 K⁺ are pumped out of the cell.

3 Na⁺ and 2 K⁺ are pumped into the cell against their concentration gradients.

3 Na⁺ are pumped out of the cell, and 2 K⁺ are pumped into the cell.

3 Na⁺ and 2 K⁺ are pumped in or out of the cell depending on their concentration gradients.

Correct.

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3.

The binding followed by release of Na⁺ and K⁺ ions to the ATPase is achieved by:

a gate within the pump that opens and closes to let ions in and out.

a change in the extracellular concentration of each ion type.

changes in the affinities of the pump for each ion type.

dimerization of the α and β subunits of the pump.

All of the above

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4.

If a mutation were created in the Na⁺/K⁺ ATPase that prevents the pump from converting to the E2 from the E1 conformation, what would be expected?

The pump would remain in a high-affinity state for Na⁺ and a low-affinity state for K⁺.

The pump would bind Na⁺ only, and not K⁺.

Na⁺ and K⁺ ions would not be transported against their concentration gradients across the plasma membrane.

The bound Na⁺ ions in the pump would not gain access to the extracellular space.

All of the above

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Chapter 11. The Plasma-Membrane Na⁺/K⁺ ATPase

Introduction

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