Chapter 13. Cotranslational Translocation of Secreted and Type I Membrane Proteins

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Animation Activity 13-11: Cotranslational Translocation of Secreted and Type I Membrane Proteins

1.

Which of the following can be shared by both secreted soluble proteins and plasma membrane proteins that are synthesized by ribosomes docked on ER translocons?

an internal signal anchor sequence

an internal signal anchor sequence and a C-terminal ER signal sequence

an N-terminal ER signal sequence and an internal signal anchor sequence

an N-terminal ER signal sequence

a C-terminal ER signal sequence

Correct.

Incorrect.

Try Again.

2.

Which of the following is NOT an activity of a Signal Recognition Particle (SRP)?

binding an ER signal sequence

arresting protein translation

interacting with an SRP receptor to dock the ribosome on a translocon

cleaving an N-terminal signal sequence from the newly synthesized protein

All are activities of an SRP.

Correct.

Incorrect.

Try Again.

3.

What is the final topology of a protein in the ER that is synthesized with an N-terminal signal sequence and one stop-transfer anchor sequence?

N-terminus in the cytosol, one transmembrane domain, C-terminus in the ER lumen

N-terminus in the cytosol, two transmembrane domains, C-terminus in the cytosol

N-terminus in the ER lumen, one transmembrane domain, C-terminus in the cytosol

N-terminus in the ER lumen, two transmembrane domains, C-terminus in the ER lumen

None of the above

Correct.

Incorrect.

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4.

If a mutation is introduced into I-ĸBα that inhibits its phosphorylation by the IKK complex, this would prevent:

translocation of NF-ĸB into the nucleus.

TAK1 phosphorylation of IKKβ.

All of the above.

recruitment of Nemo to the IKK complex.

dimerization of the p50 and p65 subunits.

Correct.

Incorrect.

Try Again.

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Chapter 13. Cotranslational Translocation of Secreted and Type I Membrane Proteins

Introduction

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