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Mechanism for Nuclear Import of Proteins

Chapter 13. Mechanism for Nuclear Import of Proteins

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Animation Activity 13-36: Mechanism for Nuclear Import of Proteins

1.

Nuclear import of proteins from the cytoplasm occurs via _______________ using the nuclear cargo protein _______________.

GTPases; importin

nuclear channels; GAP

nuclear pore complexes (NPC); importin

diffusion across nuclear membrane; GEF

importin; Ran-GTP

Correct.

Incorrect.

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2.

The function of FG-nucleoporins within the nuclear pore complex is to:

shield large, hydrophilic, unchaperoned proteins from entering the nucleus.

prevent small, hydrophobic proteins from entering the nucleus.

cleave the nuclear localization sequence (NLS) from the protein to be imported.

aid GAP in the hydrolysis of GTP to GDP.

All of the above.

Correct.

Incorrect.

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3.

Release of the cargo protein from its nuclear cargo protein into the cytoplasm is triggered by:

hydrolysis of the Ran-bound GTP to GDP via GAP.

FG-nucleoporin binding to the nuclear protein-importin complex.

the binding of importin to Ran-GTP.

All of the above.

None of the above.

Correct.

Incorrect.

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4.

Ultimately, the entire process of nuclear protein import is driven by:

the concentration gradient of the imported protein across the nuclear membrane.

the localization of GEF and GAP.

FG-nucleoporins in the nuclear pore complex (NPC).

GTP hydrolysis.

None of the above.

Correct.

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5.

Preventing GEF activity in the nucleus would prevent which of the following?

the exchange of GDP for GTP on Ran

the import of Ran-GDP into the nucleus

transport of Ran-GDP through the nuclear pore complex (NPC)

cleavage of the nuclear localization sequence (NLS)

All of the above

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Chapter 13. Mechanism for Nuclear Import of Proteins

Introduction

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