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Role of the KDEL Receptor in Retrieval of ER-Resident Luminal Proteins from the Golgi

Chapter 14. Role of the KDEL Receptor in Retrieval of ER-Resident Luminal Proteins from the Golgi

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Animation Activity 14-13: Role of the KDEL Receptor in Retrieval of ER-Resident Luminal Proteins from the Golgi

1.

The KDEL sequence on the C-termini of ER luminal proteins is necessary for:

processing the protein for secretion.

transport of the protein to the cis-Golgi.

retrieval of the protein back to the ER.

packaging the protein into COPII vesicles.

All of the above.

Correct.

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2.

The KDEL receptor is expressed in which of the following?

COPI and COPII vesicles and the cis-Golgi network

COPII vesicles and the cis-Golgi network

COPI and COPII vesicles, the cis-Golgi network, and the rough ER

COPII vesicles and the rough ER

the cis-Golgi network only

Correct.

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3.

The binding affinity of the KDEL receptor to KDEL sequences is dependent on:

temperature.

pH.

the concentration of proteins bearing the KDEL sequence.

the conformation of the KDEL sequence.

the presence of COPII vesicles.

Correct.

Incorrect.

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4.

If the pH of the rough ER were higher than normal, what might be expected of the fate of proteins bearing the KDEL sequence?

They would not be able to bind the KDEL receptor in COPII vesicles budding from the ER.

They would be able to participate in ER-to-Golgi transport.

They would not be able to exit the ER.

They would not be released from the KDEL receptor of vesicles returning to the ER.

There would be no effect, as pH plays no role on these proteins.

Correct.

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Chapter 14. Role of the KDEL Receptor in Retrieval of ER-Resident Luminal Proteins from the Golgi

Introduction

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