Chapter 15. Signal Transduction with Adenylyl Cyclase

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Animation Activity 15-07: Signal Transduction with Adenylyl Cyclase

cAMP activation of gene transcription involves all of the following EXCEPT ________.

binding of phosphorylated CREB and a coactivator protein to a CRE sequence in the promoter region of a gene.

binding of cAMP to the regulatory subunits of PKA and release of the PKA catalytic subunits.

binding of cAMP to CREB.

PKA phosphorylation of CREB.

movement of the PKA catalytic subunits into the nucleus.

Correct.

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Whether cAMP signaling activates transcription of a specific gene depends on ________.

how much cAMP is present in the cell; high levels of cAMP will turn on all genes.

the opening of nuclear pores so that cAMP can enter the nucleus.

the ratio of cAMP molecules to PKA regulatory subunits in the cell.

whether the gene contains a CRE sequence in its promoter.

whether the gene has a promoter sequence to which the coactivator CBP-P300 binds.

Correct.

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cAMP activation of genes encoding proteins involved in gluconeogenesis ________.

decreases the amount of glucose synthesized in the cell.

decreases the amount of glucose generated by glycogen breakdown.

increases the amount of glucose synthesized in the cell.

decreases the amount of glucose synthesized in the cell and increases the amount of glucose generated by glycogen breakdown.

increases the amount of glucose generated by glycogen breakdown.

Correct.

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Introduction