Chapter 16. TGF-β Signaling

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Animation Activity: 16-3: TGF-β Signaling

1.

TGF-β signaling pathway receptors RI and RII are:

tyrosine kinases.

TGF-β-gated ion channels.

phospholipases.

serine/threonine kinases.

G protein–coupled receptors (GPCRs).

Correct.

Incorrect.

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2.

Which statement is false regarding the TGF-β signaling pathway when no TGF-β is bound to TGF-β receptor II (RII)?

RI receptor kinase activity is auto-(self-)inhibited.

Smad2/3 is unphosphorylated and in the cytoplasm.

Smad4 is in the nucleus.

Transcription of the PAI-1 gene is turned off.

All of the above are true.

Correct.

Incorrect.

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3.

TGF-β Receptor I (RI) phosphorylation of Smad2/3 does all of the following EXCEPT:

unmask the Smad2/3 nuclear localization signal (NLS).

dissociate intramolecular binding of Smad2/3 MH1 and MH2 domains.

release Smad2/3 from the nucleus into the cytoplasm

activate Smad2/3 binding to the Co-Smad Smad4

RI phosphorylation of Smad2/3 does all of these things.

Correct.

Incorrect.

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4.

The complex formed by phosphorylated Smad2/3 that moves into the nucleus contains all of the following EXCEPT:

TGF-β receptor I (RI).

importin.

Smad2/3.

Smad4.

The complex contains all of the listed components.

Correct.

Incorrect.

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Chapter 16. TGF-β Signaling

Introduction

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