Chapter 16. Activation of the NF-ĸB Signaling Pathway

Animation Activities

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Animation Activity 16-35: Activation of the NF-ĸB Signaling Pathway

1.

Which of these is NOT required for activation of NF-ĸB signaling?

degradation of I-ĸBα

a stimulus such as viral infection, ionizing radiation, or pro-inflammatory cytokines

unmasking of the nuclear localization sequences (NLS) of the NF-ĸB subunits

deactivation of the IKK complex to relieve inhibition of NF-ĸB

translocation of NF-ĸB into the nucleus

Correct.

Incorrect.

Try Again.

2.

Which process is involved in targeting I-ĸBα for degradation to relieve inhibition of NF-ĸB?

phosphorylation of I-ĸBα

polyubiquitination of I-ĸBα

proteasomal degradation of I-ĸBα

binding of E3 ubiquitin ligase to I-ĸBα

All of the above.

Correct.

Incorrect.

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3.

NF-ĸB activates the transcription of all of these EXCEPT:

enzymes.

chemokines.

adhesion proteins.

toll-like receptors.

I-ĸB.

Correct.

Incorrect.

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4.

If a mutation is introduced into I-ĸBα that inhibits its phosphorylation by the IKK complex, this would prevent:

translocation of NF-ĸB into the nucleus.

dimerization of the p50 and p65 subunits.

recruitment of Nemo to the IKK complex.

All of the above.

TAK1 phosphorylation of IKKβ.

Correct.

Incorrect.

Try Again.

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Chapter 16. Activation of the NF-ĸB Signaling Pathway

Introduction

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