Chapter 21. Integration of Multiple Signaling Pathways in Vertebrate Cells that Regulate Outer Mitochondrial Membrane Permeability and Apoptosis
Introduction
Animation Activity 21-40: Integration of Multiple Signaling Pathways in Vertebrate Cells that Regulate Outer Mitochondrial Membrane Permeability and Apoptosis
1.
The dissociation of Bak/Bax from Bcl-2/Bcl-xL results in which of the following:
I. Survival of the cell
II. Mitochondrial membrane oligomeric pore formation
III. Binding of cytochrome c to Apaf-1 in the cytosol
IV. Activation of the caspase cascade
V. Binding of Bad to Bcl-2/Bcl-xL
| A. |
| B. |
| C. |
| D. |
| E. |
2.
Which of the following molecules does NOT result in activation of the apoptotic caspase cascade?
| A. |
| B. |
| C. |
| D. |
| E. |
3.
Phosphorylation of ________ leads to its interaction with a cytosolic 14-3-3 protein and prevents it from binding to ________, thus resulting in an ________ effect.
| A. |
| B. |
| C. |
| D. |
| E. |
4.
Mitochondrial membrane pore formation by Bak/Bax results in the release of which molecule into the cytosol?
| A. |
| B. |
| C. |
| D. |
| E. |
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