Chapter 24. The Development and Metastasis of Human Colorectal Cancer and Its Genetic Basis

Animation Activities

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Animation Activity 24-12: The Development and Metastasis of Human Colorectal Cancer and Its Genetic Basis

The multi-hit model of colorectal cancer involves mutations in the tumor-suppressor genes, ________ and ________, and in the oncogene ________:

APC; myc; K-ras

APC; K-ras; p53

p53; APC; K-ras

K-ras; p53; APC

APC; myc; p53

Correct.

Incorrect.

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The distribution of tumor cells to distant sites of the body via blood vessels is referred to as:

metastasis.

the multi-hit model.

invasion of the basement membrane.

genomic instability.

a malignant carcinoma.

Correct.

Incorrect.

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Mutations in multiple genes, rather than a single gene, can enable a colorectal tumor to:

grow into an adenoma from a polyp.

develop into a malignant carcinoma.

become genetically instable.

proliferate and divide uncontrollably.

All of the above

Correct.

Incorrect.

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Introduction