The Wonderful Effects of the New Inoculation!The talented caricaturist James Gillray satirized widespread anxieties about the smallpox vaccination in this lively image. The discoveries of Edward Jenner a few years prior to Gillray’s caricature had led to the adoption of a safer vaccine derived from cowpox. The artist mocks this breakthrough by showing cows bursting from the boils supposedly brought on by the vaccine. (Private Collection/The Bridgeman Art Library)