Jews in Hellenistic cities were generally treated the same as any other non-Greek group. At first they were seen as resident aliens. As they grew more numerous, they received permission to form a political corporation, a politeuma (pah-lih-TOO-mah), which gave them a great deal of autonomy. The Jewish politeuma, like the rest of the Hellenistic city, was expected to obey the king’s commands, but there was virtually no royal interference with the Jewish religion. The Seleucid king Antiochus III (ca. 242–187 B.C.E.), for instance, recognized that most Jews were loyal subjects, and in his efforts to solidify his empire he endorsed their religious customs and ensured their autonomy.

Antiochus IV Epiphanes (175–ca. 164 B.C.E.) broke with this pattern. He expanded the Seleucid kingdom and nearly conquered Egypt, but while he was there a revolt broke out in Judaea, led by Jews who opposed the Hellenized Jewish leader he had designated for them. Antiochus attacked Jerusalem, killing many, and restored his leader. According to Hebrew scripture, he then banned Jewish practices and worship, ordered copies of the Torah burned, and set up altars to the Greek gods in Jewish temples. This sparked a widespread Jewish revolt that began in 166 B.C.E., called the Revolt of the Maccabees after the name of one of its leaders. Using guerrilla tactics, the Maccabees fought Syrian troops who were fighting under Seleucid commanders, retook Jerusalem, and set up a semi-independent state in 164 B.C.E. This state lasted for about a century, until it was conquered by the Romans. (The rededication of the temple in Jerusalem after the Maccabee victory is celebrated in the Jewish holiday of Hanukkah.)

Jews living in Hellenistic cities often embraced many aspects of Hellenism. The Revolt of the Maccabees is seen by some historians, in fact, as primarily a dispute between Hellenized Jews and those who wanted to retain traditional practices. So many Jews learned Greek, especially in Alexandria, that the Hebrew Bible was translated into Greek and services in the synagogue there came to be conducted in Greek. Jews often took Greek names, used Greek political forms, adopted Greek practice by forming their own trade associations, and put inscriptions on graves as the Greeks did. Some Jews were given the right to become full citizens of Hellenistic cities, although relatively few appear to have exercised that right. Citizenship would have allowed them to vote in the assembly and serve as magistrates, but it would also have obliged them to worship the gods of the city — a practice few Jews chose to follow.