MAP 12.3 The Unification of Spain and the Expulsion of the Jews, Fifteenth Century The marriage of Ferdinand of Aragon and Isabella of Castile in 1469 brought most of the Iberian Peninsula under one monarchy, although different parts of Spain retained distinct cultures, languages, and legal systems. In 1492 Ferdinand and Isabella conquered Granada, where most people were Muslim, and expelled the Jews from all of Spain. Spanish Jews resettled in cities of Europe and the Mediterranean that allowed them in, including Muslim states such as the Ottoman Empire. Muslims were also expelled from Spain over the course of the sixteenth and early seventeenth centuries.