In 1500 scientific activity flourished in many parts of the world. With the expansion of Islam into the lands of the Byzantine Empire in the seventh and eighth centuries, Muslim scholars inherited ancient Greek learning, which itself was built on centuries of borrowing from older civilizations in Egypt, Babylonia, and India. The interaction of peoples and cultures across the vast Muslim world, facilitated by religious tolerance and the common scholarly language of Arabic, was highly favorable to advances in learning.

In a great period of cultural and intellectual flourishing from 1000 to 1500, Muslim scholars thrived in cultural centers such as Baghdad and Córdoba, the capital of Islamic Spain. They established the world’s first universities in Constantinople, Fez (Morocco), and Cairo. In this fertile atmosphere, scholars surpassed the texts they had inherited in areas such as mathematics, physics, astronomy, and medicine. Arab and Persian mathematicians, for example, invented algebra, the concept of the algorithm, and decimal point notation, while Arab astronomers improved on measurements recorded in ancient works.

China was also a vital center of scientific activity, which reached a peak in the mid-fourteenth century. Among its many achievements, papermaking, gunpowder, and the use of the compass in navigation would be the most influential for the West. In Mesoamerica, civilizations such as the Maya and the Aztecs devised complex calendar systems based on astronomical observations and developed mathematics and writing.

Given the multiple world sites of learning and scholarship, it was by no means inevitable that Europe would take the lead in scientific thought or that “modern science” as we know it would emerge. In world history, periods of advancement produced by intense cultural interaction, such as those that occurred after the spread of Islam, are often followed by stagnation and decline during times of conflict and loss of authority. This is what happened in western Europe after the fall of the Western Roman Empire in the fifth century and in the Maya civilization after the collapse of its cultural and political centers around 900. The Muslim world successfully resisted a similar threat after the Mongol invasions.

The re-establishment of stronger monarchies and the growth of trade in the High Middle Ages contributed to a renewal of learning in western Europe. As Europeans began to encroach on Islamic lands in Iberia, Sicily, and the eastern Mediterranean, they became aware of the rich heritage of Greek learning in these regions and the ways scholars had improved upon ancient knowledge. In the twelfth century many ancient Greek texts — including works of Aristotle, Ptolemy, Galen, and Euclid previously unknown in the West — were translated into Latin, along with the commentaries of Arab scholars. A number of European cities created universities in which Aristotle’s works dominated the curriculum.

As Europe recovered from the ravages of the Black Death in the late fourteenth and fifteenth centuries, the intellectual and cultural movement known as the Renaissance provided a crucial foundation for the Scientific Revolution. Scholars called humanists, working in the bustling mercantile city-states of Italy, emphasized the value of acquiring knowledge for the practical purposes of life. The quest to restore the glories of the ancient past led to the rediscovery of other classical texts such as Ptolemy’s Geography, which was translated into Latin around 1410. An encyclopedic treatise on botany by Theophrastus was rediscovered in the 1450s moldering on the shelves of the Vatican library. The fall of Constantinople to the Ottomans in 1453 resulted in a great influx of little-known Greek works, as Christian scholars fled to Italy with their precious texts.

In this period, western European universities established new professorships of mathematics, astronomy, and natural philosophy. The prestige of the new fields was low, especially mathematics, which was reserved for practical problems such as accounting, surveying, and computing planetary tables but not used as a tool to understand the functioning of the physical world itself. Nevertheless, these professorships eventually enabled the union of mathematics with natural philosophy that was to be a hallmark of the Scientific Revolution.

European overseas expansion in the fifteenth and sixteenth centuries provided another catalyst for new thought about the natural world. In particular, the navigational problems of long oceanic voyages in the age of expansion stimulated scientific research and invention. To help solve these problems, inventors developed many new scientific instruments, such as the telescope, barometer, thermometer, pendulum clock, microscope, and air pump. Better instruments, which permitted more accurate observations, often led to important new knowledge. Another crucial technology in this period was printing, which provided a faster and less expensive way to circulate knowledge.

Political and social conflicts were widespread in Eurasia in the sixteenth and early seventeenth centuries, but they had different results. The three large empires of the Muslim world (see Chapter 17) that arose in the wake of the Mongol Empire sought to restore order and assert legitimacy in part by imposing Islamic orthodoxy. Their failure to adopt the printing press (see “Intellectual Advances and Religious Trends” in Chapter 17) can be seen as part of a wider reaction against earlier traditions of innovation. Similarly, in China after the Manchu invasion of 1644, the new Qing Dynasty legitimized its authority through stricter adherence to Confucian tradition. By contrast, western Europe remained politically fragmented into smaller competitive nations, divisions that were augmented by the religious fracturing of the Protestant Reformation. These conditions made it impossible for authorities to impose one orthodox set of ideas and thus allowed individuals to question dominant patterns of thinking.