Feature siRNA miRNA
Origin mRNA, transposon, or virus RNA transcribed from distinct gene
Cleavage of RNA duplex or single-stranded RNA that forms long hairpins Single-stranded RNA that forms short hairpins of double-stranded RNA
Size 21–25 nucleotides 21–25 nucleotides
Action Degradation of mRNA, inhibition of transcription, chromatin modification Degradation of mRNA, inhibition of translation, chromatin modification
Target Genes from which they were transcribed Genes other than those from which they were transcribed
Table 14.5: Differences between siRNAs and miRNAs