Figure 20.21: Protein microarrays can be used to examine interactions among proteins. (a) A microarray containing 4400 proteins found in yeast. (b) The array was probed with an enzyme that phosphylates proteins to determine which proteins serve as substrate for the enzyme. Dark spots represent proteins that were phosphylated by the enzyme. Proteins that phosphylate themselves (autophosphorylate) are included in each block of the microarray (shown in blue boxes) to serve as reference points.
[From D. Hall, J. Ptacek, and M. Snyder, 2006. Mechanisms of Ageing and Development 128 (2007) 161-167. © 2006, with permission from Elsevier.]