Gene Encodes Action of Gene
Xist lncRNA Coats inactive X chromosome and leads to silencing of transcription of many genes on the inactive X
Tsix lncRNA Inhibits transcription of Xist on active X chromosome
Jpx lncRNA Stimulates transcription of Xist on inactive X chromosome
Xite lncRNA Sustains Tsix expression on active X, which inhibits Xist and maintains transcription of genes on active X chromosome
Table 21.2: Major genes involved in X inactivation