| Gene | Normal function | Cancer in which gene is mutated |
|---|---|---|
| APC | Scaffold protein, interacts with microtubules | Colorectal |
| CDKN2A | Regulates cell division | Melanoma |
| BRCA1 | DNA repair, transcription factor | Breast and ovarian |
| NF1 | GTPase activator | Neurofibromatosis |
| p53 | Regulates cell division | Many types of cancer |
| RB | Regulates cell division | Retinoblastoma |