Articles on ethical issues in genetics are preceded by an asterisk.

Adams, M. D., S. E. Celniker, R. A. Holt, et al. 2000. The genome sequence of Drosophila melanogaster. Science 287:2185–2195.

A report on the complete sequence of the fruit fly Drosophila melanogaster.

Aebersold, R., and M. Mann. 2003. Mass spectrometry-based proteomics. Nature 422:198–207.

A review article about the use of mass spectrometry to study proteins.

Arabidopsis Genome Initiative. 2000. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796–815.

An analysis of the first complete plant genome to be published.

Bowman, J. L., S. K. Floyd, and K. Sakakibara. 2007. Green genes: comparative genomics of the green branch of life. Cell 129:229–234.

A concise review of how genomics is changing our understanding of the relationships among groups of plants.

C. elegans Sequencing Consortium. 1998. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282:2012–2018.

A report on the sequence and analysis of the genome of the nematode C. elegans.

Chimpanzee Sequencing and Analysis Consortium. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 473:69–87.

A report on the genome sequence of the chimpanzee.

*Choe, M. K., D. Magnus, A. L. Caplan, et al. 1999. Ethical considerations in synthesizing a minimal genome. Science 286:2087–2090.

A discussion of some of the ethical implications of creating novel organisms by constructing a minimal genome.

Collins, F. 2010. Has the revolution arrived. Nature 464:674–675.

The leader of the Human Genome Project discusses the role of genomes in the future of personalized medicine.

Cox, J., and M. Mann. 2007. Is proteomics the new genomics? Cell 130:395–398.

A brief discussion of the challenges and promises of proteomics.

Davies, K. 2001. Cracking the Genome: Inside the Race to Unlock Human DNA. New York: Simon & Schuster.

A very readable account of the history of the Human Genome Project, placed within the context of advances in molecular biology.

Dean, P. M., E. D. Zanders, and D. S. Bailey. 2001. Industrial-scale genomics-based drug design and discovery. Trends in Biotechnology 19:288–292.

A review of the effect of genomics on drug discovery and design.

Domon, B., and R. Aebersold. 2006. Mass spectrometry and protein analysis. Science 312:212–217.

A nice review of spectrometric methods for detecting and analyzing proteins.

Drmanac, R. 2012. The ultimate genetic test. Science 336:1110–1112.

A discussion of the future role of whole-genome sequencing in the practice of medicine.

Drosophila 12 Genome Consortium. 2007. Evolution of genes and genomes on the Drosophila phylogeny. Nature 450:203–218.

A summary of the genomes from 12 Drosophila species. There are a number of additional articles in this issue of Nature on comparative genomics of Drosophila.

Dymond, J. S., et al. 2011. Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature 477:471–476.

Report on progress toward creating an entirely synthetic yeast cell.

Eisenberg, D., E. M. Marcotte, I. Xenarios, et al. 2000. Protein function in the post-genomic era. Nature 405:823–826.

A review of how protein function can be inferred from DNA sequence data.

Fraser, C. M., J. Eisen, R. D. Fleischmann, et al. 2001. Comparative genomics and understanding of microbial biology. Emerging Infectious Diseases 6:505–512.

An excellent overview of what has been learned from whole-genome sequences of prokaryotic organisms.

R17

Gibson, D. G., G. A. Benders, C. Andrews-Pfannkoch, et al. 2008. Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome. Science 319:1215–1220.

A report of the synthesis of a complete genome.

Green, R. E., J. Krause, A. W. Briggs, et al. 2010. A draft sequence of the Neandertal genome. Science 328:710–722.

Initial report on the results of the sequencing of the complete Neanderthal genome.

Hall, S. S. 2010. Revolution postponed. Scientific American (October): 60–67.

Discussion of disappointment over the failure of the human genome project to influence the practice of medicine.

Honeybee Genome Sequencing Consortium. 2006. Insights into social insects from the genome of the honeybee Apis mellifera. Nature 443:931–948.

A report on the sequencing and analysis of the honeybee genome.

Howard, K. 2000. The bioinformatics gold rush. Scientific American 283(1): 58–63.

A good overview of bioinformatics and its economic potential. In this issue of Scientific American, see also articles titled “The human genome business today” and “Beyond the human genome.”

Hugenholtz, P., and G. W. Tyson. 2008. Metagenomics. Nature 455:481–483.

A short review of the metagenomics approach.

International HapMap Consortium. 2005. A haplotype map of the human genome. Nature 437:1299–1320.

A report on single-nucleotide polymorphisms.

International Human Genome Sequencing Consortium. 2001. Initial sequencing and analysis of the human genome. Nature 409:860–921.

A report from the public consortium on its version of the human genome sequence. Many articles in this issue of Nature report on various aspects of the human genome.

International SNP Map Working Group. 2001. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409:928–933.

A report on mapping single-nucleotide polymorphisms in the human genome.

Kitzman, J. O., M. W. Snyder, M. Ventura, et al. 2012. Noninvasive whole-genome sequencing of a human fetus. Science Translational Medicine 4:137ra76.

Report of the complete sequencing of a fetus genome from DNA isolated from the mother’s blood.

Knight, J. 2001. When the chips are down. Nature 410:860–861.

A news story about progress in using DNA chips to monitor gene expression.

Lander, E. S. 2011. Initial impact of the sequencing of the human genome. Nature 470:187–197.

A review of the impact of the human genome project on the tenth anniversity of the first sequencing of the human genome. See also other articles in this same issue of Nature.

Lee, W., Z. Jiang, J. Liu, et al. 2010. The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature 465:473–477.

Results from the complete genome sequencing of cancer cells and normal cells from a person with lung cancer.

Mewes, H. W., K. Albermann, M. Bahr, et al. 1997. Overview of the yeast genome. Nature 387:7–8.

A broad look at the yeast genome and what can be learned from its sequence.

Miller, W., D. I. Drautz, A. Ratan, et al. 2008. Sequencing the nuclear genome of the extinct wooly mammoth. Nature 456:387–390.

A report of the sequencing of the complete genome of the extinct wooly mammoth.

Nóbrega, M. A., Y. Zhu, I. Plajzer-Frick, et al. 2004. Megabase deletions of gene deserts result in viable mice. Nature 431:988–993.

A research report on the deletion of large gene deserts in mice.

Pennisi, E. 2011. Green genomes. Science 332:1372–1375.

Discussion of the impact of sequencing over 30 plant genomes on our understanding of plant evolution.

Rosamond, J., and A. Allsop. 2000. Harnessing the power of the genome in the search for new antibiotics. Science 287:1973–1976.

Describes how genome sequences can be useful in the search for new drugs.

Sander, C. 2000. Genomic medicine and the future of health care. Science 287:1977–1978.

A discussion of the effect of genomics on the future of medicine.

Service, R. F. 2008. Proteomics ponders prime time. Science 321:1758–1761.

A journalistic account of the current state of proteomics.

Telovich, T. M., K. Musunuru, A. V. Smith, et al. 2010. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466:707–713.

Genome-wide study of variation in human lipids and coronary artery disease.

The 1000 Genomes Project Consortium. 2010. A map of human genome variation from population-scale sequencing. Nature 467:1061–1073.

Results from a pilot study of the 1000 Genomes Project, an effort to characterize human genetic variation.

Turnbaugh, P. J., R. E. Ley, M. A. Mahowald, et al. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1022–1023.

A report on metagenomics research showing that obesity may by influenced by the microbial community of the gut.

Turnbaugh, P. J., and J. I. Gordon. 2008. An invitation to the marriage of metagenomics and metabolomics. Cell 134:708–713.

An essay on how metagenomics is being used to study the composition and metabolism of microbial communities.

Venter, J. C., M. D. Adams, E. W. Myers, et al. 2001. The sequence of the human genome. Science 291:1304–1351.

An analysis of the private draft of the human genome sequence. Much of this issue of Science reports on the human genome sequence and its analysis.

Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661–678.

A report on the use of 500,000 single-nucleotide polymorphisms to look for associations between genes and seven common diseases.

R18

Whitfield. C. W., S. K. Behura, S. H. Berlocher, et al. 2006. Thrice out of Africa: ancient and recent expansions of the honeybee Apis mellifera. Science 314:642–645.

A research report that examines the origin and evolution of the honeybee by using DNA sequence data.

Yang, J., B. Benyamin, B. P. McEvoy, et al. 2010. Common SNPs explain a large proportion of the heritability for human height. Nature Genetics 42:565–569.

Report of a genome-wide association study that identified many genes that contribute to variation in human height.