Articles on ethical issues in genetics are preceded by an asterisk.

R19

Allen, H. L., K. Estrada, G. Lettre, et al. 2010. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832–838.

Report of a very large genome-wide association study of human height involving data from over 183,000 individuals.

Beltrao, P., G. Cagney, and N. J. Krogan. 2010. Quantitative genetic interactions reveal biological modularity. Cell 141:739–745.

A review of how genetic interactions affect quantitative traits.

Buckler, E. S., J. B. Holland, P. J. Bradbury, et al. 2009. The genetic architecture of maize flowering time. Science 325:714–718.

Reports on the identification of QTLs that affect flowering time in corn.

Cunningham, P. 1991. The genetics of thoroughbred horses. Scientific American 264(5): 92–98.

An interesting account of how quantitative genetics is being applied to the breeding of thoroughbred horses.

Dudley, J. W. 1977. 76 generations of selection for oil and protein percentage in maize. In E. Pollak, O. Kempthorne, and T. B. Bailey, Jr., eds., Proceedings of the International Conference on Quantitative Genetics, pp. 459–473. Ames: Iowa State University Press.

A report on the progress of one of the longest-running selection experiments.

East, E. M. 1910. A Mendelian interpretation of variation that is apparently continuous. American Naturalist 44:65–82.

East’s interpretation of how individual genes acting collectively produce continuous variation, including a discussion of Herman Nilsson-Ehle’s research on kernel color in wheat.

East, E. M. 1916. Studies on size inheritance in Nicotiana. Genetics 1:164–176.

East’s study of flower length in Nicotiana.

Falconer, D. S., and T. F. C. MacKay (Contributor). 1996. Introduction to Quantitative Genetics, 4th ed. New York: Addison-Wesley.

An excellent basic textbook on quantitative genetics.

Frary, A., T. C. Nesbitt, A. Frary, et al. 2000. A quantitative trait locus key to the evolution of tomato fruit size. Science 289:85–88.

A report on the discovery and cloning of one QTL that is responsible for the quantitative difference in fruit size between wild tomatoes and cultivated varieties.

Freathy, R. M., D. O. Mook-Kanamori, U. Sovio, et al. 2010. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics 42:430–435.

Analysis of genome-wide association studies that located genes influencing birth weight in humans.

Fridman, E., F. Carrari, Y. Liu, et al. 2004. Zooming in on a quantitative trait for tomato yield using interspecific introgression. Science 305:1786–1789.

Research report on the use of QTL analysis to locate a gene that plays an important role in sugar yield in tomatoes.

Gillham, N. W. 2001. Sir Francis Galton and the birth of eugenics. Annual Review of Genetics 2001:83–101.

A history of Galton’s contributions to the eugenics movement.

Glazier, A. M., J. H. Nadeau, and T. J. Aitman. 2002. Finding genes that underlie complex traits. Science 298:2345–2349.

A discussion of some of the methods used to find genes affecting complex quantitative traits and what standards should exist to establish the influence of genes on QTLs.

Jones, P., K. Chase, A. Martin, et al. 2008. Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics 178:1033–1044.

A report on research using genome-wide association studies to locate genes that affect size and behavioral traits in dogs.

Mackay, T. F. C. 2001. The genetic architecture of quantitative traits. Annual Review of Genetics 35:303–339.

A review of techniques for QTL mapping and results from studies on QTLs.

Martienssen, R. 1997. The origin of maize branches out. Nature 386:443–445.

A discussion of the identification of QTLs that contributed to the domestication of corn.

Moore, K. J., and D. L. Nagle. 2000. Complex trait analysis in the mouse: the strengths, the limitations, and the promise yet to come. Annual Review of Genetics 43:653–686.

A review of the genetic analysis of complex characteristics in mice, particularly emphasizing those that are medically important.

Nordborg, M., and D. Weigel. 2008. Next generation genetics in plants. Nature 456:720–723.

A review article on the use of genome-wide association studies to find genes that affect quantitative traits in plants.

Paterson, A. H., E. S. Lander, J. D. Hewitt, et al. 1988. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature 335:721–726.

A report on a study identifying QTLs that control fruit mass, pH, and other important characteristics in tomatoes.

Plomin, R. 1999. Genetics and general cognitive ability. Nature 402:C25–C29.

A good discussion of the genetics of general intelligence and the search for QTLs that influence it.

Song, X., W. Huang, M. Shi, et al. 2007. A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase. Nature Genetics 39:623–630.

Reports on the use of QTL mapping to locate a gene that plays an important role in rice grain shape.

Tian, F., P. J. Bradbury, P. J. Brown, et al. 2011. Genome-wide association study of leaf architecture in the maize nested association mapping population. Nature Genetics 43:159–168.

Study of QTLs for leaf architecture in corn.

Van Laere, A., M. Nguyen, M. Braunschweig, et al. 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832–836.

A research report on a gene associated with increased muscle mass in pigs.

Wright, S. I., I. V. Bi, S. G. Schroeder, et al. 2005. The effects of artificial selection on the maize genome. Science 308:1310–1314.

Describes the use of single-nucleotide polymorphisms to better understand how corn was domesticated.

Zheng, P., W. B. Allen, K. Roesler, et al. 2008. A phenylalanine in DGAT is a key determinant of oil content and composition in maize. Nature Genetics 40:367–372.

R20

A research report on a gene that controls increased oil production in corn.

Zimmer, C. 2008. The search for intelligence. Scientific American 299(4): 68–75.

A readable account of research that is attempting to locate genes that influence intelligence in humans.