Chapter 5

Articles on ethical issues in genetics are preceded by an asterisk.

Altshuler, D., M. J. Daly, and E. S. Lander. 2008. Genetic mapping in human disease. Science 322:881–888.

A review of powerful new methods for identifying and mapping genes that affect human traits.

Hillers, K. J. 2004. Crossover interference. Current Biology 14:R1036–R1037.

A brief review of crossover interference.

Hillmer, A. M. 2008. Susceptibility variants for male-pattern baldness on chromosome 20p11. Nature Genetics 40:1279–1281.

Reports on a genome-wide association study on genes that influence pattern baldness.

Hillmer, A. M., S. Hanneken, S. Ritzmann, et al. 2005. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenic alopecia. American Journal of Human Genetics 77:140–148.

Reports that pattern baldness is caused by variation at the androgen receptor gene on the X chromosome.

Hillmer, A., V. Moskvina, R. Sims, et al. 2008. Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. American Journal of Human Genetics 82:737–743.

Reports that pattern baldness is also influenced by one or more genes on chromosome 3.

Kong, A., D. F. Gudbjartsson, J. Sainz, et al. 2002. A high-resolution recombination map of the human genome. Nature Genetics 31:241–247.

A detailed report on how recombination varies across the human genome.

Kong, A., G. Thorleifsson, D. F. Gudbjartsson, et al. 2010. Fine-scale recombination rate differences between sexes, populations, and individuals. Nature 467:1099–1103.

Another research report on recombination rates across the human genome.

Lichten, M., and B. de Massey. 2011. The impressionistic landscape of meiotic recombination. Cell 147:267–270.

A brief review of recent studies that mapped recombination sites across the genomes of yeast and mice.

Myers, S., L. Bottolo, C. Freeman, et al. 2005. A fine-scale map of recombination rates and hotspots across the human genome. Science 310:321–324.

More on recombination in the human genome.

Richards, J. B. 2008. Male-pattern baldness susceptibility locus at 20p11. Nature Genetics 40:1282–1284.

Research report showing that genetic variation on chromosome 20 also contributes to pattern baldness.

Winckler, W., S. R. Myers, D. J. Richter, et al. 2005. Comparison of fine-scale recombination rates in humans and chimpanzees. Science 308:107–111.

A research report describing recombination hotspots in the genomes of humans and chimpanzees.

Yokoo, R., K. A. Zawadzki, K. Nabeshima, et al. 2012. COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers. Cell 149:75–86.

A research report on molecular mechanisms that control crossovers.