Sister of James Otis and wife of James Warren, both prominent Massachusetts revolutionaries, Mercy Otis Warren was well positioned to learn about revolutionary politics from the ground up. Abigail and John Adams were close friends until she broke with them in the late 1780s over her support for Antifederalism. In 1788, Warren published a pamphlet explaining her well-argued objections to the Constitution. Photograph © 2012 Museum of Fine Arts, Boston, Bequest of Winslow Warren, 31.212.