INFOGRAPHIC 31.10 ANTIGENIC DRIFT AND SHIFT CREATE NEW INFLUENZA STRAINS
Mutation and gene exchange are two mechanisms by which influenza viruses can change. Mutations that accumulate gradually can cause variations in surface antigen. This process is called antigenic drift. Different strains can also swap genes and cause surface antigens to change more dramatically. This is called antigenic shift. Drift is responsible for annual seasonal variation in influenza; shift is responsible for dramatic pandemics.