5.26 Treating prostate disease. A large study used records from Canada’s national health care system to compare the effectiveness of two ways to treat prostate disease. The two treatments are traditional surgery and a new method that does not require surgery. The records described many patients whose doctors had chosen one or the other method. The study found that patients treated by the new method were significantly more likely to die within eight years.
(a) Further study of the data showed that this conclusion was wrong. The extra deaths among patients treated with the new method could be explained by lurking variables. What lurking variables might be confounded with a doctor’s choice of surgical or nonsurgical treatment? For example, why might a doctor avoid assigning a patient to surgery?
(b) You have 300 prostate patients who are willing to serve as subjects in an experiment to compare the two methods. Use a diagram to outline the design of a randomized comparative experiment.