4.6 The Chemical Senses: Adding Flavor

Somatosensation is all about physical changes in or on the body: Vision and audition sense energetic states of the world—light and sound waves—and touch is activated by physical changes in or on the body surface. The last set of senses we’ll consider share a chemical basis to combine aspects of distance and proximity. The chemical senses of olfaction (smell) and gustation (taste) respond to the molecular structure of substances floating into the nasal cavity as you inhale or dissolving in saliva. Smell and taste combine to produce the perceptual experience we call flavor.

Smell

Olfaction is the least understood sense and the only one directly connected to the forebrain, with pathways into the frontal lobe, amygdala, and other forebrain structures (recall from the Neuroscience and Behavior chapter that the other senses connect first to the thalamus). This mapping indicates that smell has a close relationship with areas involved in emotional and social behavior. Smell seems to have evolved in animals as a signaling sense for the familiar: a friendly creature, an edible food, or a sexually receptive mate.

Countless substances release odors into the air, and some of their odorant molecules make their way into our noses, drifting in on the air we breathe. Situated along the top of the nasal cavity shown in FIGURE 4.27 is a mucous membrane called the olfactory epithelium, which contains about 10 million olfactory receptor neurons (ORNs), receptor cells that initiate the sense of smell. Odorant molecules bind to sites on these specialized receptors, and if enough bindings occur, the ORNs send action potentials into the olfactory nerve (Dalton, 2003).

Figure 4.27: Anatomy of Smell Along the roof of the nasal cavity, odorant molecules dissolve in the mucous membrane that forms the olfactory epithelium. Odorants may then bind to olfactory receptor neurons (ORNs) embedded in the epithelium. ORNs respond to a range of odors and, once activated, relay action potentials to their associated glomeruli in the olfactory bulb, located just beneath the frontal lobes. The glomeruli synapse on neurons whose axons form the olfactory nerve, which projects directly into the forebrain.

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How many scents can humans smell?

Taste and smell both contribute to what we perceive as flavor. This is why smelling the bouquet of a wine is an essential part of the wine-tasting ritual. The experience of wine tasting is also influenced by cognitive factors, such as knowledge of a wine’s price.
ALUMA IMAGES/MASTERFILE/RADIUS IMAGES

Each olfactory neuron has receptors that bind to some odorants but not to others, as if the receptor is a lock and the odorant is the key (see FIGURE 4.27). Groups of ORNs send their axons from the olfactory epithelium into the olfactory bulb, a brain structure located above the nasal cavity beneath the frontal lobes. Humans possess about 350 different ORN types that permit us to discriminate among some 10,000 different odorants through the unique patterns of neural activity each odorant evokes. This setup is similar to our ability to see a vast range of colors based on only a small number of retinal receptor cell types or to feel a range of skin sensations based on only a handful of touch receptor cell types.

Some dogs have as many as 100 times more ORNs than humans do, producing a correspondingly sharpened ability to detect and discriminate among millions of odors. Nevertheless, humans are sensitive to the smells of some substances in extremely small concentrations. For example, a chemical compound that is added to natural gas to help detect gas leaks can be sensed at a concentration of just 0.0003 part per million. By contrast, acetone (nail polish remover), something most people regard as pungent, can be detected only if its concentration is 15 parts per million or greater.

The olfactory bulb sends outputs to various centers in the brain, including the parts that are responsible for controlling basic drives, emotions, and memories. Odor perception includes both information about the identity of an odor, which involves relating olfactory inputs to information stored in memory (Stevenson & Boakes, 2003), as well as our emotional response to whether it is pleasant or unpleasant (Khan et al., 2007). Which of these processes occurs first? When you walk into a house and encounter the wonderful smell of freshly baked chocolate chip cookies, does your positive emotional response come before you identify the smell or vice versa? According to the object-centered approach, information about the identity of the “odor object” is quickly accessed from memory and then triggers an emotional response (Stevenson & Wilson, 2007). According to the valence-centered approach, the emotional response comes first and provides a basis for determining the identity of the odor (Yeshrun & Sobel, 2010). Recent attempts to distinguish between these two views support that odor perception is guided first by memory and then by emotion (Olofsson et al., 2012).

The relationship between smell and emotion explains why smells can have immediate, strongly positive or negative effects on us. If the slightest whiff of an apple pie baking brings back fond memories of childhood or the unexpected sniff of vomit mentally returns you to a particularly bad party you once attended, you’ve got the idea. Thankfully, sensory adaptation is at work when it comes to smell, just as it is with the other senses. Whether the associations are good or bad, after just a few minutes the smell fades. Smell adaptation makes sense: It allows us to detect new odors that may require us to act, but after that initial evaluation has occurred, it may be best to reduce our sensitivity to allow us to detect other smells.

Our experience of smell is determined not only by bottom-up influences, such as odorant molecules binding to sites on ORNs, but also by top-down influences, such as our previous experiences with an odor (Gottfried, 2008). Consistent with this idea, people rate the identical odor as more pleasant when it is paired with an appealing verbal label such as cheddar cheese rather than an unappealing one such as body odor (de Araujo et al., 2005; Herz & von Clef, 2001). fMRI evidence indicates that brain regions involved in coding the pleasantness of an experience, such as the orbiotofrontal cortex, respond more strongly to the identical odor when people think it is cheddar cheese than when they think it is a body odor (de Araujo et al., 2005; see the Hot Science box, Taste for the Top Down, for a related finding concerning taste perception).

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HOT SCIENCE: Taste: From the Top Down

In 2008, the publication of a book titled The Wine Trials (Goldstein & Herschkowitsch, 2008) ruffled the feathers of more than a few wine connoisseurs. The book was based on an article in which the authors and several colleagues analyzed the results of 6,175 observations gathered during 17 blind wine tastings involving wines of varying prices, organized by lead author and food critic Robin Goldstein (Goldstein, Almenberg, Dreber, Emerson, Herschkowitsch, & Katz, 2008). The results suggested that, if anything, tasters liked the more expensive wines slightly less than the more inexpensive ones.

Although these findings will not encourage ordinary wine drinkers to spend a large amount of money on their next wine purchase, they leave open the question of whether knowing a wine’s price affects enjoyment of it. Similar to olfaction, our experience of taste is partly determined by bottom-up influences, such as the patterns of activity in the five taste receptor types that are evoked by food molecules, but it is also influenced by top-down factors, such as knowing what brand we are eating or drinking.

To investigate the effects of a top-down influence (price knowledge) on the enjoyment of wine and associated brain activity, researchers used fMRI to scan 20 participants while they drank different wines or a control solution (Plassman et al., 2008). The participants were told that they would be sampling five different cabernet sauvignons, that the different wines would be identified by their price, and that they should rate how much they liked each wine. The participants did not know, however, that only three different wines were actually presented, and that two critical wines were presented twice. One critical wine was presented once at its actual price ($5) and once marked-up to a high price ($45); the other critical wine was also presented once at its actual price ($90) and once at a marked-down price ($10). This design allowed the researchers to compare ratings and brain activity for the identical wine when participants thought it was expensive or cheap.

Results revealed that during scanning, participants reported liking both wines better when they were accompanied by a high price than by a low price. For the fMRI analysis, the researchers focused on the activity of the medial orbitofrontal cortex (mOFC), a part of the brain located deep inside the frontal lobe that is known to be involved in coding the pleasantness of an experience (Kuhn & Gallinat, 2012). The level of mOFC activity was closely correlated with subjective ratings of taste pleasantness in a previous fMRI study (Kringelbach et al., 2003). As shown in the accompanying figure, there was greater mOFC activity for both wines in the high price condition than in the low price condition.

These results demonstrate clearly that taste experience and associated neural activity can be affected by top-down influences such as price knowledge. Related work has shown that other top-down influences, such as expectations, can also affect both taste experience and brain responses (Nitschke et al., 2006). Consider a recent fMRI study in which researchers manipulated whether participants expected that a liquid they were about to taste would be sweet or tasteless (Veldhuizen et al., 2011). On most trials, the participants’ expectations were met: They were cued to expect a sweet or a tasteless liquid and then received the type of liquid indicated by the cue. On some trials, though, their expectations were violated: They were cued to expect a sweet or a tasteless liquid and then received the opposite. When expectations were violated either by receiving a sweet or a tasteless stimulus, activity in a number of brain regions showed increased activity, reflecting in part a general “surprise” response. However, a part of the brain’s taste system known as the anterior insula showed the most activity when the unexpected stimulus contained the sweet taste, thus indicating that top-down influences can affect a part of the brain known to be involved in the experience of taste.

The results of these studies should provide some comfort to wine drinkers who are willing to pay for expensive brands. Even if they can’t tell the difference from cheaper brands under blind tasting conditions, just knowing that they’re drinking an expensive wine should make for an enjoyable experience.

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Smell may also play a role in social behavior. Humans and other animals can detect odors from pheromones, biochemical odorants emitted by other members of its species that can affect the animal’s behavior or physiology. Parents can distinguish the smell of their own children from other people’s children. An infant can identify the smell of its mother’s breast from the smell of other mothers. Pheromones also play a role in reproductive behavior in insects and in several mammalian species, including mice, dogs, and primates (Brennan & Zufall, 2006). Can the same thing be said of human reproductive behavior?

Studies of people’s preference for the odors of individuals of the opposite sex have produced mixed results, with no consistent tendency for people to prefer them over other pleasant odors. Recent research, however, has provided a link between sexual orientation and responses to odors that may constitute human pheromones. Researchers used positron emission tomography (PET) scans to study the brain’s response to two odors, one related to testosterone, which is produced in men’s sweat, and the other related to estrogen, which is found in women’s urine. The testosterone-based odor activated the hypothalamus (a part of the brain that controls sexual behavior; see the Neuroscience and Behavior chapter) in heterosexual women but not in heterosexual men, whereas the estrogen-based odor activated the hypothalamus in heterosexual men but not in women. Strikingly, homosexual men responded to the two chemicals in the same way as women did: The hypothalamus was activated by the testosterone-but not estrogen-based odor (Savic, Berglund, & Lindstrom, 2005; see FIGURE 4.28). Other common odors unrelated to sexual arousal were processed similarly by all three groups. A follow-up study with lesbian women showed that their responses to the testosterone- and estrogen-based odors were largely similar to those of heterosexual men (Berglund, Lindstrom, & Savic, 2006). Taken together, the two studies suggest that some human pheromones are related to sexual orientation.

Figure 4.28: Smell and Social Behavior In a PET study, heterosexual women, homosexual men, and heterosexual men were scanned as they were presented with each of several odors. During the presentation of a testosterone-based odor (referred to in the figure as AND), there was significant activation in the hypothalamus for heterosexual women (left) and homosexual men (center) but not for (right) heterosexual men (Savic et al., 2005).
IVANKA SAVIC, HA BERGLUND, AND PER LINDSTROM

Taste

Why is the sense of taste an evolutionary advantage?

One of the primary responsibilities of the chemical sense of taste is identifying things that are bad for you—as in poisonous and lethal. Many poisons are bitter, and we avoid eating things that nauseate us for good reason, so taste aversions have a clear adaptive significance. Some aspects of taste perception are genetic, such as an aversion to extreme bitterness, and some are learned, such as an aversion to a particular food that once caused nausea. In either case, the direct contact between a tongue and possible foods allows us to anticipate whether something will be harmful or palatable.

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The tongue is covered with thousands of small bumps, called papillae, which are easily visible to the naked eye. Within each papilla are hundreds of taste buds, the organ of taste transduction (see FIGURE 4.29). The mouth contains 5,000 to 10,000 taste buds fairly evenly distributed over the tongue, roof of the mouth, and upper throat (Bartoshuk & Beauchamp, 1994; Halpern, 2002). Each taste bud contains 50 to 100 taste receptor cells. Taste perception fades with age (Methven et al., 2012): On average, people lose half their taste receptors by the time they turn 20. This may help to explain why young children seem to be “fussy eaters,” since their greater number of taste buds brings with it a greater range of taste sensations.

Figure 4.29: A Taste Bud Taste buds stud the bumps (papillae) on the tongue, shown here, as well as the back, sides, and roof of the mouth (a). Each taste bud contains a range of receptor cells that respond to varying chemical components of foods called tastants (b). Tastant molecules dissolve in saliva and stimulate the microvilli that form the tips of the taste receptor cells (c). Each taste bud contacts the branch of a cranial nerve at its base.
Fussy eater or just too many taste buds? Our taste perception declines with age: We lose about half of our taste receptors by the time we’re 20 years old. That can make childhood a time of either savory delight or a sensory overload of taste.
LESLIE BANKS/ISTOCKPHOTO.COM

The human eye contains millions of rods and cones, the human nose contains some 350 different types of olfactory receptors, but the taste system contains just five main types of taste receptors, corresponding to five primary taste sensations: salt, sour, bitter, sweet, and umami (savory). The first four are quite familiar, but umami may not be. In fact, perception researchers are still debating its existence. The umami receptor was discovered by Japanese scientists who attributed it to the tastes evoked by foods containing a high concentration of protein, such as meats and cheeses (Yamaguchi, 1998). If you’re a meat eater and you savor the feel of a steak topped with butter or a cheeseburger as it sits in your mouth, you’ve got an idea of the umami sensation.

Each taste bud contains several types of taste receptor cells whose tips, called microvilli, react with tastant molecules in food. Salt taste receptors are most strongly activated by sodium chloride (table salt). Sour receptor cells respond to acids, such as vinegar or lime juice. Bitter and sweet taste receptors are more complex. Some 50 to 80 distinct binding sites in bitter receptors are activated by an equal number of different bitter-tasting chemicals. Sweet receptor cells likewise can be activated by a wide range of substances in addition to sugars.

Although umami receptor cells are the least well understood, researchers are homing in on their key features (Chandrashekar et al., 2006). They respond most strongly to glutamate, an amino acid in many protein-containing foods. Recall from the Neuroscience and Behavior chapter, glutamate acts as a neurotransmitter; in fact, it’s a major excitatory neurotransmitter. The food additive monosodium glutamate (MSG), which is often used to flavor Asian foods, particularly activates umami receptors. Some people develop headaches or allergic reactions after eating MSG.

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SAM GROSS/THE NEW YORKER COLLECTION/CARTOONBANK.COM

Of course, the variety of taste experiences greatly exceeds the five basic receptors discussed here. Any food molecules dissolved in saliva evoke specific, combined patterns of activity in the five taste receptor types. Although we often think of taste as the primary source for flavor, in fact, taste and smell collaborate to produce this complex perception. As any wine connoisseur will attest, the full experience of a wine’s flavor cannot be appreciated without a finely trained sense of smell. Odorants from substances outside your mouth enter the nasal cavity via the nostrils, and odorants in the mouth enter through the back of the throat. This is why wine aficionados are taught to pull air in over wine held in the mouth: It allows the wine’s odorant molecules to enter the nasal cavity through this “back door.” (The taste of wine can also be influenced by cognitive factors, as illustrated in the Hot Science box.)

You can easily demonstrate the contribution of smell to flavor by tasting a few different foods while holding your nose, preventing the olfactory system from detecting their odors. If you have a head cold, you probably already know how this turns out. Your favorite spicy burrito or zesty pasta probably tastes as bland as can be.

Taste experiences also vary widely across individuals. About 50% of people report a mildly bitter taste in caffeine, saccharine, certain green vegetables, and other substances, whereas roughly 25% report no bitter taste. Members of the first group are called tasters and members of the second group are called nontasters. The remaining 25% of people are supertasters, who report that such substances, especially dark green vegetables, are extremely bitter, to the point of being inedible (Bartoshuk, 2000). Children start out as tasters or supertasters, which could help explain their early tendency toward fussiness in food preference. However, some children grow up to become nontasters. Because supertasters tend to avoid fruits and vegetables that contain tastes they experience as extremely bitter, they may be at increased health risk for diseases such as colon cancer. On the other hand, because they also tend to avoid fatty, creamy foods, they tend to be thinner and may have decreased risk of cardiovascular disease (Bartoshuk, 2000). There is evidence that genetic factors contribute to individual differences in taste perception (Kim et al., 2003), but much remains to be learned about the specific genes that are involved (Hayes et al., 2008; Reed, 2008).

  • Our experience of smell, or olfaction, is associated with odorant molecules binding to sites on specialized olfactory receptors, which converge at the glomerulus within the olfactory bulb. The olfactory bulb in turn sends signals to parts of the brain that control drives, emotions, and memories, which helps to explain why smells can have immediate and powerful effects on us.
  • Smell is also involved in social behavior, as illustrated by pheromones, which are related to reproductive behavior and sexual responses in several species.
  • Sensations of taste depend on taste buds, which are distributed across the tongue, roof of the mouth, and upper throat and on taste receptors that correspond to the five primary taste sensations of salt, sour, bitter, sweet, and umami.
  • Taste experiences vary widely across individuals and, like olfactory experiences, depend in part on cognitive influences.

OTHER VOICES: Hallucinations and the Visual System

We rely on our perceptual systems to provide reliable information about the world around us. Yet we’ve already seen that perception is prone to various kinds of illusions. Even more striking, our perceptual systems are capable of creating hallucinations: perceptions of sights, sounds, or other sensory experiences that don’t exist in the world outside us. As discussed by the by perceptual psychologist V.S. Ramachandran in an interview with the New York Times, reported in an article written by Susan Kruglinski, vivid visual hallucinations can even occur in low vision or even blind individuals with severe damage to their retinas.

One day a few years ago, Doris Stowens saw the monsters from Maurice Sendak’s “Where the Wild Things Are” stomping into her bedroom. Then the creatures morphed into traditional Thai dancers with long brass fingernails, whose furious dance took them from the floor to the walls to the ceiling.

Although shocked to witness such a spectacle, Ms. Stowens, 85, was aware that she was having hallucinations, and she was certain that they had something to do with the fact that she suffered from the eye disease macular degeneration.

“I knew instantly that something was going on between my brain and my eyes,” she said.

Ms. Stowens says that ever since she developed partial vision loss, she has been seeing pink walls and early American quilts floating through the blind spots in her eyes several times each week.

In fact, Ms. Stowens’s hallucinations are a result of Charles Bonnet syndrome, a strange but relatively common disorder found in people who have vision problems. Because the overwhelming majority of people with vision problems are more than 70 years old, the syndrome, named after its 18th-century Swiss discoverer, is mostly found among the elderly. And because older people are more susceptible to cognitive deterioration, which can include hallucinations or delusions, Charles Bonnet (pronounced bon-NAY) is easily misdiagnosed as mental illness.

Many patients who have it never consult a doctor, out of fear that they will be labeled mentally ill.

“It is not a rare disorder,” said Dr. V. S. Ramachandran, a neurologist at the University of California at San Diego, who has written about the syndrome. “It’s quite common. It’s just that people don’t want to talk about it when they have it.”

Researchers estimate that 10 to 15 percent of people whose eyesight is worse than 20/60 develop the disorder. Any eye disease that causes blind spots or low vision can be the source, including cataracts, glaucoma, diabetic retinopathy and, most commonly, macular degeneration. The hallucinations can vary from simple patches of color or patterns to lifelike images of people or landscapes to phantasms straight out of dreams. The hallucinations are usually brief and nonthreatening, and people who have the syndrome usually understand that what they are seeing is not real….

In some ways, researchers say, the hallucinations that define the syndrome are similar to the phenomenon of phantom limbs, where patients still vividly feel limbs that have been amputated, or phantom hearing, where a person hears music or other sounds while going deaf. In all three cases, the perceptions are caused by a loss of the sensory information that normally flows unceasingly into the brain.

In the case of sight, the primary visual cortex is responsible for taking in information, and also for forming remembered or imagined images. This dual function, Dr. Ramachandran and other experts say, suggests that normal vision is in fact a fusion of incoming sensory information with internally generated sensory input, the brain filling in the visual field with what it is used to seeing or expects to see. If you expect the person sitting next to you to be wearing a blue shirt, for example, you might, in a quick sideways glance, mistakenly perceive a red shirt as blue. A more direct gaze allows for more external information to correct the misperception.

“In a sense, we are all hallucinating all the time,” Dr. Ramachandran said. “What we call normal vision is our selecting the hallucination that best fits reality.”

With extensive vision loss, less external information is available to adjust and guide the brain’s tendency to fill in sensory gaps. The results may be Thai dancers or monsters from a children’s book….

Charles Bonnet syndrome was first described over 250 years ago by Bonnet, a Swiss scientist whose own blind grandfather experienced hallucinations like those reported by Ms. Stowens. However, neurologists and others have only recently begun to study the syndrome. Can you make some sense of this syndrome based on what you have learned about the visual system? How can someone who sees poorly or cannot see at all have intense visual experiences? What brain processes could be responsible for these kinds of visual hallucinations? Some clues come from neuroimaging studies of people who experience visual hallucinations, which have shown that specific types of hallucinations are accompanied by activity in parts of the brain responsible for the particular content of the hallucinations (Allen, LarØi, McGuire, & Aleman, 2008). For example, facial hallucinations are accompanied by activity in a part of the temporal lobe known to be involved in face processing. Our understanding of the visual system beyond the retina can provide some insight into how and why blind individuals experience visual hallucinations.

From the New York Times, September 14, 2004 © 2004 The New York Times. All rights reserved. Used by permission and protected by the Copyright Laws of the United States. The printing, copying, redistribution, or retransmission of this Content without express written permission is prohibited. http://www.nytimes.com/2004/09/14/science/14eyes.html

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