Chapter 11. Chapter 11: Single-Gene Inheritance and Meiosis
Introduction
Driving Questions
1. How does the organization of chromosomes, genes and their alleles contribute to human traits?
2. How does meiosis produce gametes?
3. Why do different traits have different inheritance patterns?
4. What are practical applications of understanding the genetic basis of human disease?
Overview
The presentation is organized around the driving questions, with opportunities for active and collaborative learning built into each driving question (e.g. brainstorming, clicker questions and mini-cases). Students have the opportunity to consider their understanding of each driving question before you move on to the next.
Pre-Class Preparation for Students
1. Assign the first section of the chapter as a reading (up to the heading “How is CF Inherited?”)
2. Post a link to Emily’s Audition Tape to get on the Ellen Show, ask students to watch it (it is ~2:35 mins in length).
3. Assign Animation 11.3 (LaunchPad). This is an interactive activity to introduce the concept of diploid cells, haploid gametes and fertilization
For a tutorial on how to assign resources in LaunchPad, please click here.
During Class
Use (or modify) the lecture slides (available for download below). The lectures slides start with a review of the prep assignment (collaborative discussion and clicker questions), then move through each Driving Question. The slides include additional information and notes in the “Notes” section under each slide (visible in “Normal” or “Notes Page” view).
After Class
1. Assign the entire chapter as an after-class reading
2. Select additional practice questions (e.g. from the end of chapter or LaunchPad resources) for students to complete.
Particular ones to consider:
- Animation 11.5 (LaunchPad) (this addresses the genetic diversity of gametes produced by meiosis, and includes some multiple choice questions)
- Animation 11.7 and 11.8 (LaunchPad) (this is a single animation with a drag and drop activity that addresses recessive and dominant inheritance as well as inheritance of two genes)
- End of Chapter questions 10, 12, 17, 19 and 21
3. (Optional) Have students investigate other genetic diseases. You could have them choose their own, or you could assign diseases based on features such as:
- inheritance pattern (recessive or dominant)
- availability of treatments
- whether or not widespread genetic testing is available
Timing Estimates
Intro: ~5 mins (including review of their prep)
Driving Question 1: ~20-25 minutes
Driving Question 2: ~20-25 minutes
Driving Question 3: ~20 minutes
Driving Question 4: ~20 minutes
Supplemental Resources
A summary of the story for this chapter is available for download by clicking on the image below. This summary contains a brief abstract, as well as an outline of the key points in the story. It can be used as a refresher on the chapter narrative to help prepare you for class.
Additional References
Ivacaftor:
Ivacaftor trial:
Ramsey, B.W. et al. (2011). A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. New Engl J Med 365:1663-1672.