| 1800 | - Thomas Jefferson and Aaron Burr tie in electoral college.
- Gabriel’s rebellion reported.
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| 1801 | - House of Representatives elects Jefferson president.
- Barbary War with Tripoli begins.
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| 1803 | - Marbury v. Madison.
- United States warned not to ship war goods to Britain or France.
- Louisiana Purchase.
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| 1804 | - United States defeats Tripoli
- Jefferson meets with Osage Indians.
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| 1804-1806 | - Lewis and Clark expedition.
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| 1807 | - Chesapeake incident.
- Embargo Act.
- United States establishes trade with Comanche Indians.
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| 1808 | - James Madison elected president.
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| 1809 | - Treaty of Fort Wayne.
- Non-Intercourse Act.
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| 1811 | |
| 1812 | - United States declares war on Great Britain.
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| 1813 | - Tecumseh dies at battle of the Thames.
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| 1814 | - British attack Washington City.
- Treaty of Ghent.
- Hartford Convention.
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| 1815 | |
| 1816 | - James Monroe elected president.
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| 1819 | |
| 1820 | |
| 1823 | - Monroe Doctrine asserted.
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| 1825 | - John Quincy Adams elected president by House of Representatives.
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