| 1606 | - Virginia Company receives royal charter.
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| 1607 | - English colonists found Jamestown; Pocahontas “rescues” John Smith.
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| 1607–1610 | - Starvation plagues Jamestown.
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| 1612 | - John Rolfe begins to plant tobacco in Virginia.
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| 1617 | - First commercial tobacco shipment to England.
- Pocahontas dies in England.
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| 1618 | - Powhatan dies; Opechancanough becomes Algonquian chief.
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| 1619 | - First Africans arrive in Virginia.
- House of Burgesses begins to meet.
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| 1622 | - Opechancanough leads first uprising in Virginia.
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| 1624 | - Virginia becomes royal colony.
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| 1630s | - Barbados colonized by English.
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| 1632 | - Colony of Maryland founded.
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| 1634 | - Colonists begin to arrive in Maryland.
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| 1640s | - Barbados colonists grow sugarcane with slave labor.
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| 1644 | - Opechancanough leads second uprising.
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| 1660 | - Navigation Act requires colonial products be shipped only to English ports.
- Virginia law defines slavery as inherited, lifelong servitude.
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| 1663 | |
| 1670 | - Charles Towne, South Carolina, founded.
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| 1670–1700 | - Slave labor system emerges in Carolina and Chesapeake colonies.
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| 1676 | |
| 1680 | |