Figure 18.10 Response of the pyruvate dehydrogenase complex to the energy charge. The pyruvate dehydrogenase complex is regulated to respond to the energy charge of the cell. (A) The complex is inhibited by its immediate products, NADH and acetyl CoA, as well as by the ultimate product of cellular respiration, ATP. (B) The complex is activated by pyruvate and ADP, which inhibit the kinase that phosphorylates PDH.