Figure 25.8 Glucose regulates liver-glycogen metabolism. In the liver, glucose binds to glycogen phosphorylase a and inhibits it, facilitating the formation of the t state of phosphorylase a. the t state of phosphorylase a does not bind protein phosphatase 1 (PP1), leading to the dissociation of PP1 from glycogen phosphorylase a and its subsequent activation. The free PP1 dephosphorylates glycogen phosphorylase a and glycogen synthase b, leading to the inactivation of glycogen breakdown and the activation of glycogen synthesis.