Our thanks go to the instructors and professors who have reviewed the chapters of this book. Their sharp eyes and keen insights strongly influenced us as we wrote and shaped the various drafts of each chapter to create this completed work.

Tabitha Amora, Ball State University

Bynthia Anose, Bethel University

Kimberly Bagley, SUNY Buffalo State

David Baker, Delta College

Michael Barbush, Baker University

Ellen Batchelder, Unity College

Moriah Beck, Wichita State University

Nina Bernstein, MacEwan University

Veronic Bezaire, Carleton University

Mary Bruno, University of Connecticut

John Cannon, Trinity International University

James Cheetham, Carleton University

Silvana Constantinescu, Marymount California University

Peter DiMaria, Delaware State University

Caryn Evilia, Idaho State University

Brenda Fredette, Medaille College

Scott Gabriel, Viterbo University

Ratna Gupta, Our Lady of the Lake College

Sarah Hosch, Oakland University

Kelly Johanson, Xavier University of Louisiana

Marjorie Jones, Illinois State University

Susan Knock, Texas A&M University at Galveston

Kris Koudelka, Point Loma Nazarene University

Ramaswamy Krishnamoorthi, Kansas State University

Isabel Larraza, North Park University

Linda Luck, SUNY Plattsburgh

Kumaran Mani, University of Wyoming

Jairam Menon, University of Michigan Medical School

David Mitchell, College of Saint Benedict & Saint John’s University

Mautusi Mitra, University of West Georgia

Ashvin Mohindra, Fleming College

William Newton, Virginia Tech

Brian Nichols, University of Illinois at Chicago

Carleitta Paige-Anderson, Virginia Union University

Janice Pellino, Carthage College

Ivana Peralta, Vincennes University

Elizabeth Roberts-Kirchhoff, University of Detroit Mercy

John Rose, University of Georgia

Martina Rosenberg, University of New Mexico

Tricia Scott, Dalton State College

Richard Sheardy, Texas Woman’s University

Kevin Siebenlist, Marquette University

Matt Thomas, State College of Florida

Jennifer Tsui, Marygrove College

Timothy Vail, Northern Arizona University

Todd Weaver, University of Wisconsin–La Crosse

Korin Wheeler, Santa Clara University

Harvey Wiener, Manchester Community College

Marc Wold, University of Iowa

Adele Wolfson, Wellesley College

The German scientist, writer, and statesman Johann Wolfgang von Goethe once remarked, “Thinking is easy, acting is difficult, and to put one’s thoughts into action is the most difficult thing in the world.” While we may disagree with Goethe’s assertion that thinking is easy, we emphatically agree with the rest of the quotation. Thinking about biochemistry and then putting those thoughts into a book that is clear, welcoming, stimulating, and challenging is, if not the most difficult thing in the world, still very demanding. This task would be utterly impossible without our wonderful colleagues at W. H. Freeman. They are intelligent, dedicated, caring people who have taught us much about how to present science to students and, in the process, brought out the best in us. Although we have had the pleasure of working with our collaborators at W. H. Freeman on a number of projects, our appreciation of and gratefulness for their efforts and guidance are as sincere now as they were when we were inexperienced authors. Our experiences with this edition have been as delightful and rewarding as our past projects. We have many people to thank for this experience, some of whom we have worked with previously and some new to the effort. First, we would like to acknowledge the encouragement, patience, excellent advice, and good humor of our Publisher, Kate Ahr Parker. Kate can suggest difficult challenges with such grace and equanimity that we readily accept the challenge. New to our book team is our Senior Acquisitions Editor, Lauren Schultz. Her unfailing enthusiasm was a source of support and energy for the author team. New to our book team for this edition is Heidi Bamatter, our Developmental Editor. Heidi is another in a line of outstanding development editors that we have had the pleasure to work with at Freeman. Her insight, patience, and guidance made this effort successful and enjoyable. Elizabeth Geller, Senior Project Editor, managed the flow of the project with admirable efficiency. Teresa Wilson, our Manuscript Editor, enhanced the literary consistency and clarity of the text. Vicki Tomaselli, Design Manager, produced a design and layout that made the book welcoming and accessible. ­Christine Buese and Jacquelyn Wong, Photo Editor and Photo Researcher, respectively, found the photographs that helped to achieve one of our main goals—linking biochemistry to the everyday world of the student while making the text a visual treat. Janice Donnola, Illustration Coordinator, deftly directed the rendering of new illustrations. Paul Rohloff, Production Manager, made sure the difficulties of scheduling, composition, and manufacturing were readily overcome. We are more appreciative of the sales staff at W. H. Freeman for their enthusiastic support than we can put into words. Without the efforts of the sales force to persuade professors to examine our book, all of our own excitement and enthusiasm for this text would be meaningless. We also thank Susan Winslow. Her vision for science ­textbooks and her skill at gathering exceptional personnel make working with W. H. Freeman a true pleasure.

Thanks also to our many colleagues at our own institutions as well as throughout the country who patiently answered our questions and encouraged us on our quest. Finally, we owe a debt of gratitude to our families. Without their support, comfort, and understanding, this project could never have been undertaken, let alone successfully completed.