Four years later, in the election of 1888, fickle voters turned Cleveland out, electing Republican Benjamin Harrison, the grandson of President William Henry Harrison. Then, in the only instance in American history when a president once defeated at the polls returned to office, the voters brought Cleveland back in the election of 1892. What factors account for such a surprising turnaround? The 1880s witnessed a remarkable political realignment as a set of economic concerns replaced appeals to Civil War sectional loyalties. The tariff, federal regulation of the railroads and trusts, and the campaign for free silver restructured American politics. Then a Wall Street panic in 1893 set off a major depression that further fed political unrest.