There are seven coordinating conjunctions in English: and, but, or, nor, for, so, and yet. When a coordinating conjunction joins independent clauses, it is usually preceded by a comma.
However is a transitional expression, not a coordinating conjunction, so it cannot be used with only a comma to join independent clauses.
Related topic:
Commas with coordinating conjunctions
coordinating conjunction and, but, or, nor, for, so, yet; used to join elements of equal grammatical form.