An appositive is a noun or noun phrase that renames a nearby noun. Nonrestrictive appositives are set off with commas; restrictive appositives are not.
Most important restricts the meaning to one book, so the appositive On the Origin of Species is nonrestrictive and should be set off with commas.
Albuterol is a specific drug; a bronchial dilator adds useful but not essential information, so it is set off with commas.
Once they’ve read song, readers still don’t know precisely which song the writer means. The appositive following song restricts its meaning.
The sentence does not make sense without specifying the exact English word, so it cannot be set off with commas.
Exercises:
Major uses of the comma 1
Major uses of the comma 2
All uses of the comma
Related topics:
Commas and restrictive and nonrestrictive elements: Overview
Distinguishing between restrictive and nonrestrictive from context
Commas with adjective clauses
Commas with adjective phrases