Table 23.2: Dependence of the half-lives of cytoplasmic yeast proteins on the identity of their amino-terminal residues

Highly stabilizing residues (t1/2 > 20 hours)

Ala

Pro

Cys

Ser

Gly

Thr

Met

Val

Intrinsically destabilizing residues (t1/2 = 2 to 30 minutes)

Arg

Lys

His

Phe

Ile

Trp

Leu

Tyr

Destabilizing residues after chemical modification (t1/2 = 3 to 30 minutes)

Asn

Asp

Gln

Glu

Data from J. W. Tobias, T. E. Schrader, G. Rocap, and A. Varshavsky. Science 254(1991):1374–1377.