Table 28.2:

Disease

Selected Genes

Repair Pathway

Xeroderma pigmentosum (skin)

XPA, XPB, XPC

Nucleotide excision repair

Lynch syndrome (colon cancer)

MSH2, MLH1

Mismatch repair

Breast and ovarian cancer

BRCA1 and BRCA2

Double-strand break repair

Renal and lung cancer

OGG1

Base excision repair