Specificity pocket of chymotrypsin. Notice that this pocket is lined with hydrophobic residues and is deep, favoring the binding of residues with long hydrophobic side chains such as phenylalanine (shown in green). The active-site serine residue (serine 195) is positioned to cleave the peptide backbone between the residue bound in the pocket and the next residue in the sequence. The key amino acids that constitute the binding site are identified.