15.4 Depressive Disorders

Everybody feels depressed sometimes. A bad exam grade, a bad haircut, rejection by a college, or rejection by somebody you asked out on a date can ruin your mood for hours or days. Yet these temporary changes in mood are not what psychologists mean by “depression.” To a psychologist, the term refers to a condition that is more severe. Depression is a psychological disorder that includes feelings of sadness, hopelessness, and fatigue; a loss of interest in activities; and changes in typical patterns of eating and sleep. In depression, these symptoms last for weeks (National Institute of Mental Health [NIMH], 2011).

The term “depression” does not refer to a single disorder. Rather, there is a family of depressive disorders, that is, distinct psychological conditions that each include depressive symptoms. Let’s explore two prominent depressive disorders: Major Depressive Disorder and Bipolar Disorder (previously called Manic-Depressive Disorder). As we review them, and also when we review anxiety disorders later in this chapter, we will cover two main topics: (1) the given disorder’s defining features and its prevalence (i.e., the number of people in a population who have the disorder), and (2) therapies that effectively treat the disorder.

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Major Depressive Disorder

Preview Questions

Question

What defines major depressive disorder and how prevalent is it?

What therapies effectively treat major depressive disorder?

“It hit me what a complete mess I had made of my life. That hit me quite hard. We were as skint [poor] as you can be without being homeless and at that point I was definitely clinically depressed. That was characterized by a numbness, a coldness and an inability to believe you will feel happy again. All the color drained out of life” (ABC News, 2009).

The woman quoted above was suffering from major depression. But it didn’t ruin her life. She managed to cope quite successfully, in part—by writing a novel, and then another novel, and another. They constituted the Harry Potter series. J. K. Rowling’s epic novels (and their associated movies) originated in her need to overcome a psychological disorder, major depression.

Depression in fact and fiction J. K. Rowling’s Harry Potter series includes, among its cast of characters, Dementors, creatures that create despair and depression among those they encounter. The fictional creations reflect Rowling’s own experience battling major depression.

DEFINING FEATURES AND PREVALENCE. Major depressive disorder is defined by a set of symptoms; a person is diagnosed with major depressive disorder only if these symptoms last two weeks or longer. They include the following:

No one symptom is necessary in order to be diagnosed with the disorder. Individuals with major depression are people who exhibit a majority of the symptoms for at least a two-week period.

Major depression is a relatively prevalent disorder. A survey of U.S. adults indicated that 6.7% of the population suffered from major depressive disorder at some point during the previous year (Kessler et al., 2005). That’s about 15 million people experiencing a disorder that brings despair and lethargy that can utterly disrupt one’s life. Furthermore, the lifetime prevalence of the disorder—that is, the percentage of people who experience the disorder at least once in their life—is even higher, about 15% (Kessler et al., 1997).

Every day, though, sometimes more than once a day, sometimes all day, a coppery taste in my mouth, which I termed intense insipidity, heralded a session of helpless, bottomless misery in which I would lie curled in a foetal position on the sofa with tears leaking from my eyes, my brain boiling with the confusion of stuff not worth calling thought or imagery: it was more like shredded mental kelp marinated in pure pain. During and after such attacks, I would be prostrate with inertia, as if all my energy had gone into a black hole.

—Les Murray, Killing the Black Dog

Different groups have varying chances of becoming depressed. Major depression is more frequent among people living in poverty than among those above the poverty line (Riolo et al., 2005). Ethnic groups also differ. In one large-scale study of Americans of European, African, and Mexican ancestry, European Americans were the most likely to experience severe major depression. African Americans and Mexican Americans had higher rates of dysthymic disorder, a prolonged period of low mood whose symptoms are not as severe as those of major depression (Riolo et al., 2005). Finally, in the population at large, women are more likely to experience depression at some point in their lifetime than are men (Kessler et al., 1997).

TREATMENT. A number of the treatment strategies discussed earlier in this chapter have been used successfully to treat major depression. Let’s now look at four options: behavior therapy, cognitive therapy, interpersonal therapy (which draws from psychodynamic and humanistic therapies), and drug therapy.

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Behavioral therapists emphasize that the environment affects people’s psychological life. Some environmental events make almost anyone feel bad, whereas others make virtually everyone feel good. People become depressed, according to the behavioral approach, when they do not experience enough pleasant activities (Lewinsohn & Graf, 1973). If you sit around by yourself doing nothing at all, day after day—and thereby experience no pleasant events—you’ll eventually feel depressed.

What, then, should you do to alleviate depression? The behavioral strategy involves two steps. First, therapists instruct clients to keep track of both their daily activities and their mood during these activities; this enables clients to see how environmental events trigger good and bad moods. Second, therapists devise strategies that enable clients to avoid events that trigger depression and to engage in more activities that improve mood. One team of behavior therapists applied this approach when working with a depressed single mother. They found that the woman had eliminated virtually all positive social events from her life in order to cope with the demands of parenting. Therapists showed her how to increase her social contacts while also handling depressing household chores more efficiently so that she would have time for a social life. After a few weeks, her mood substantially improved (Lewinsohn, Sullivan, & Grosscup, 1980).

In what environments do you experience good moods?

A second approach is cognitive therapy. Aaron Beck (1987) identified a “cognitive triad”—three interconnected types of thoughts—that contribute to depression. People who are depressed tend to have excessively negatively thoughts about (1) themselves, (2) the world, and (3) the future. If a relationship breaks up and you think (1) “I’m unattractive,” (2) “The dating scene is a cruel meat market,” and (3) “I’ll never be in a relationship again,” you are exhibiting the cognitive triad of negative beliefs. In therapy, cognitive therapists challenge these thoughts and help clients replace them with ones that are more accurate and adaptive.

Good news for people suffering from depression is that cognitive therapy works. Meta-analyses that summarize the effectiveness of therapy have long shown that cognitive therapy significantly reduces symptoms of depression (Dobson, 1989). As we’ve seen, cognitive therapy is not the only effective therapy strategy, and there is some question about whether cognitive therapy is superior to all alternative approaches to psychotherapy (Cuijpers et al., 2008). Nonetheless, there is no question that cognitive therapy substantially reduces depressive symptoms.

Friends can lift your mood To treat depression, behavior therapists may instruct clients to engage in more positive social activities, such as hanging out with friends. Social activities can improve mood.

Another effective approach is interpersonal therapy. In interpersonal therapy, therapists try to identify, and change, interpersonal problems that contribute to a client’s current depression. A key aim is to reduce the client’s social isolation by expanding his or her network of relationships (Klerman et al., 1984). Interpersonal therapy is inspired by two of the broad therapy strategies you learned about earlier: the psychodynamic approach, which, in developments made after Freud’s lifetime, began to emphasize the importance of analyzing client’s interpersonal relationships (Sullivan, 1953); and the humanistic approach, whose central tenet is that strong interpersonal relationships are the foundation of healthy psychological growth. In practice, interpersonal therapy is similar to cognitive therapy for depression, with both approaches targeting irrational thoughts about interpersonal relationships (Ablon & Jones, 2002).

A fourth strategy to combat depression is drug therapy. Antidepressants are among the most widely prescribed of all prescription drugs in the United States. Nearly 1 in 10 women, and about half as many men, take antidepressants (Barber, 2008; Breggin & Breggin, 2010).

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THIS JUST IN

Do Antidepressants Work Better Than Placebos?

Americans spend and spend on antidepressant drugs. Prozac, one popular antidepressant, attained annual sales of $800 million just a few years after its 1988 release (Stipp, 2005). Today, Americans shell out $10 billion a year on antidepressant medicines—the second-most prescribed class of drugs in the United States (Hensley, 2011). If people are spending $10 billion, the drugs must be working great, right?

The exact answer depends on how “working” is defined. People who take antidepressants do improve compared with people who receive no treatment (no medication, no psychotherapy) for their depression. In this sense, then, antidepressants work. But as the psychologist Irving Kirsch (2010) emphasizes, this does not mean that the active ingredients in antidepressant drugs effectively reduce depression. The problem is that substances with no active ingredients whatsoever—that is, placebo substances—also reduce depression.

Placebo effects are fundamentally psychological, not biochemical (Kirsch, 2010). When people take prescribed substances, they expect them to work; the prescriptions give people hope. Hope combats the feelings of hopelessness that accompany depression. As a result, depressed people who take medication improve. This improvement occurs whether the drugs are real pharmaceuticals or placebos; both instill hope and reduce depression. Placebos can even induce changes in brain activity that resemble changes found in people taking real medication (Benedetti et al., 2005; Figure 15.3).

How much better is it than plain water? Research findings raise questions about the effectiveness of antidepressant medications, such as Prozac, in treating mild and moderate depression.

The key question, then, is whether antidepressant drugs work better than placebos. Kirsch (2010) reviewed all existing research studies on this question, and found the difference between drug effects and placebo effects to be remarkably small. Specifically, 82% of the effects of drugs were due to placebo effects. In other words, there was a unique effect of drugs, but it was only about 20% larger than the effect obtained from placebos. Even this 20%, Kirsch argues, is small. On a 52-point measurement scale used to measure people’s level of depression, the advantage of drugs over placebos was only 1.8 points—a difference that is statistically significant but, in practice, not that big (Kirsch, 2010). For many people, the effect is even smaller. The drug–placebo difference is larger for people who are very severely depressed and smaller for the many people who are only moderately depressed.

Others reach similar conclusions. One research team reviewed therapy outcomes among more than 700 individuals with mild, severe, or very severe levels of depression. Among people whose depression levels were very severe, antidepressant drugs were of substantial benefit. But for the remaining two-thirds of the population, with depression in the mild-to-severe range, the “benefit of antidepressant medication [was] … minimal to nonexistent” (Fournier et al., 2010, p. 47). Another meta-analysis, involving more than 4,000 patients, reached similarly pessimistic conclusions (Pigott et al., 2010).

THINK ABOUT IT

When a therapy works, ask why. What are its active ingredients—the components that actually caused it to succeed? Did a drug work because of its chemical substances or merely because taking a drug caused people to believe they would improve? Did people benefit from a psychotherapy strategy because of specific components of that strategy or merely because they had a warm, socially skilled individual (therapist) who was paying attention to them?

A final bit of evidence “just in” compares the effects of antidepressant medication to a simple intervention: exercise. Reviews of research findings indicate that, for mild to moderate levels of depression, a program of intense physical exercise is as effective as anti-depressant medications in alleviating depression (Carek et al., 2011; Cooney et al., 2013).

Like most people, I used to think that antidepressants worked.

—Irving Kirsch (2010, p. 1)

WHAT DO YOU KNOW?…

Question 9

True or False?

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  • VWonjSIJwC3+spF0MrPFSqG0lZhNKMRLj6gsmVz3DkWKLSSEsgeT5puq0E00KC/oEREpq1msu5FzRrRV7HNfGT81JtIuwaszx/Kwb1yo/H81A9FtdVX3JpaW61ju5SuECFwu1TPLDJPbLEJERsI5P0IeTih8qBaDzcjZvIAakONO2W1PKXMj0jckTFE=
figure 15.3 DO FAKE (PLACEBO) DRUGS HAVE PSYCHOLOGICAL EFFECTS?

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Because both drug therapies and psychotherapy are available to treat depression, a significant question for people experiencing the disorder is how the different therapy strategies compare. Much research has investigated this question. Findings commonly indicate either that cognitive therapy is superior to drugs in relieving major depression or that the two approaches are about equally effective (Butler et al., 2006; Cox et al., 2012). Drug therapy rarely is found to be superior. In light of recent findings comparing antidepressant drugs to placebo medications (see This Just In), this result is not surprising. Antidepressant medications have proven to be less effective than the pharmaceutical industry, and depression sufferers, had hoped.

WHAT DO YOU KNOW?…

Question 10

7N5z4qytQXc9glr5xXyZp0qwHtn2rTx27zRN2b6u7sImyN+A03vW5xlWQM1t2o0NZ6844MKLjuW9nDgd9BjzoP/uZiOdV8jPhjFhC1zQL/gEw+fSm89biqxn8Nd7MeTEjbZvffbtR4OFNMemY/8e92UUK6Ea4mxLPCJoj0n0jWhaNFIsDsiAynYvClDag/n/rCnpDD9yOkqMj587oosYJNBV5DL7NZsxqi2HfmXFB0/dYzv4kcBPM+PDfLFoulPX3mE1MRLrbftNykV/4kbUjXYF8+fIvMSZ9c2cCT2emvOkaTYntfup6KgbSeScfYGGiy+gsBwiwonU97QpEz1jVpLH3Y88CIfDbg+vf151cFEUg23+wfgURBvVQ2vwNYT1cSSLYk8+bRPpGOG5mgXUfEsWJaKuI/E2czbHG/ibht2T9AIv1DhmZxxssRn6XfkT3iQ+stKeTTH0HDaDWLY3q2oM5w6DMpWNJpbCKOjB/jSN9H32Duj9X2YD2d33VpN8RMX8yOw8o6eP67gTuSFkSEiZwOIVpMka3rlLwCBBpu9JqSuJFxl44g==
This statement is incorrect because an individual only has to experience a majority of these symptoms for two weeks in order to be diagnosed with major depressive disorder.

Question 11

Aaron Beck observed that individuals with major depression displayed a cognitive triad of negative thoughts about themselves, the world, and the Gv955PoguL/ubb5P. Research indicates that cognitive therapy is superior to, or at least equal to 8rDCTfcElmozJA7j therapies in relieving the symptoms of major depression.

CULTURAL OPPORTUNITIES

Diagnosing Disorders

People in all cultures experience psychological disorders. But do they experience the same disorders?

In the United States, a particularly common disorder is major depression. As you learned in the main text, its central features are prolonged low mood and feelings of personal worthlessness and hopelessness.

You might expect that diagnoses of major depression would be common everywhere in the world. They aren’t. Research conducted in Hunan, a large province of South-Central China, shows that diagnoses of major depression there are rare (Kleinman & Kleinman, 1985). Far more common are diagnoses of “neurasthenia.” This diagnostic category differs from depression in that its main features are not thoughts and emotions of the mind, but physical conditions of the body: fatigue, insomnia, and headache.

The difference in diagnostic categories used in the United States and China has two possible causes. People in the different countries may experience fundamentally different disorders. Alternatively, they may experience similar disorders but think and talk about them differently. Cultural differences may affect how people conceptualize their personal distress. Some evidence supports the latter view.

Researchers (Kleinman & Kleinman, 1985) carefully analyzed the psychological conditions of 100 Hunanese patients diagnosed with neurasthenia. The vast majority of them, they found, showed signs of major depression as it is diagnosed in the United States. In other words, even though they were diagnosed in China with neurasthenia, not depression, in the United States, major depression would have been the diagnosis.

What accounts for this discrepancy? It appeared that when the Chinese patients talked to their Chinese physicians, their conversations did not focus on the patient’s thoughts and emotional life. Rather, as in other non-Western cultures (Tsai & Chentsova-Dutton, 2002), Chinese patients and physicians discussed bodily states more than thoughts and feelings. This tendency reflects long-held cultural beliefs (Kleinman & Kleinman, 1985). In China, unlike the United States, prolonged sadness can bring shame upon oneself and one’s family. People thus are reluctant to talk about such emotion. Furthermore, traditional Chinese medicine suggests that the expression of negative emotion is a cause of illness, which further adds to people’s reluctance to discuss their depressed mood.

Mental health is a worldwide issue When diagnosing and treating psychological disorders, mental health professionals must pay attention to cultural factors that can influence how people experience, and discuss, psychological distress. Shown is a government-run mental health facility in the Indian state of Jammu and Kashmir, whose population experiences high rates of anxiety and stress disorders due to ongoing, and often violent, political conflicts in the region.

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Thus, cultural factors shape the way health professionals discuss and diagnose the conditions of their patients.

WHAT DO YOU KNOW?…

Question 12

In Hunan, major wghD5aUvBBjyKn8zyv+ChQ== is less likely to be diagnosed than in the United States, largely because of what the Hunanese hEpBujmSmuckGI0s about when describing their symptoms. They tend to focus on 6MhwiLlPjx4lZQQEF8FOEQ== symptoms and not emotional ones because, in their culture, sadness is shameful.

Bipolar Disorder

Preview Questions

Question

What defines bipolar disorder and how prevalent is it?

What therapies effectively treat bipolar disorder?

“I have two moods. One is … rollicking … the wild ride of a mood. [The other] stands on the shore and sobs … Sometimes the tide is in, sometimes it’s out.”

The writer suffers from bipolar disorder, also known as manic-depressive disorder. Bipolar disorder is a depressive disorder characterized by extreme variations in mood. People’s mood “swings” from severe depression to mania, which is a period of abnormally high energy, arousal, and positive mood.

Intense positive mood might sound like fun. But to people with bipolar disorder, both depression and mania bring difficulties (Gruber, 2011). In manic states, people sometimes engage in reckless behavior they later regret. It’s “a world of bad judgment calls,” the writer above continues. During the manic periods, “[I display] every kind of bad judgment because it all seems like a good idea at the time. A great idea. … So if it’s talking, if it’s shopping, if it’s—the weirdest one for me is sex. That’s only happened twice. But then it’s wow, who are you?”

Like J. K. Rowling, this writer also overcame her depressive disorder and achieved great professional success. She is Carrie Fisher—Star Wars ’s Princess Leia, one of the great heroines of film history. “I outlasted my problems,” says Fisher. “I am mentally ill. I can say that. I am not ashamed of that. I survived that, I’m still surviving it, but bring it on. Better me than you” (Prime Time, 2000).

Battling bipolar disorder As Princess Leia in Star Wars, Carrie Fisher battled Darth Vader and Jabba the Hutt. Off screen, Carrie Fisher is one of millions of Americans who have battled bipolar disorder.

In her memoir entitled Wishful Drinking, Carrie Fisher reacts to learning that her image graced the title page of an abnormal psychology textbook chapter on bipolar disorder: “Obviously my family is so proud. Keep in mind, though, I’m a PEZ dispenser and I’m in the Abnormal Psychology textbook. Who says you can’t have it all?” (Fisher, 2008, p. 114)

DEFINING FEATURES AND PREVALENCE. To be categorized according to the DSM as a person with bipolar disorder, an individual must display two types of symptoms:

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These mood swings, from depression to mania and back, distinguish bipolar disorder from major depression. Note that a person with bipolar disorder generally will experience substantial periods of normal mood state; the deviations from this state are what characterize the disorder.

About 1% of adults suffer from bipolar disorder (NIMH, 2007). In terms of overall numbers of people, then, bipolar disorder is quite prevalent; in the United States alone, 1% of adults translates into about 2 million people. Bipolar disorder is a long-term illness for which there is no surefire cure. The personal and social costs of the disorder are huge and include high risks of suicide; estimates of suicide rates among persons diagnosed with the disorder range from 8 to 20% (Nakic, Krystal, & Bhagwagar, 2010). Because it is prevalent, severe, and chronic, the World Health Organization ranks it as the sixth most severe of all medical disorders in terms of years of life lost to disability and death (Nakic et al., 2010).

TREATMENT. The primary form of treatment for bipolar disorder is drug therapy. The reasoning behind drug therapy is that bipolar disorder’s mood swings may stem from abnormal variations in brain functioning. The brain’s neurotransmitter systems generally are seen as the biological culprits (Nakic et al., 2010). Mood stabilizers, which are drugs designed to influence neurotransmitters in the brain in a manner that calms and steadies the patient’s swinging mood states, thus are a major form of treatment (Stahl, 2002).

Three types of drugs are most commonly used as mood stabilizers (Stahl, 2002):

  1. Lithium: The drug lithium, a chemical compound that centrally includes the physical element lithium, is the classic drug of choice for treating bipolar disorder. Findings support its effectiveness. Lithium reduces bipolar symptoms, even in long-term use among patients who take the drug for years (Tondo, Baldessarini, & Floris, 2001).

  2. Anticonvulsants: As we’ve seen, sometimes drugs used to treat one disorder turn out to benefit another. Anticonvulsants, which are drugs used to treat epileptic seizures, also reduce bipolar symptoms (Bowden, 2009).

  3. Antipsychotics: As you’ll learn in the next chapter, a variety of drugs are used to treat psychotic disorders such as schizophrenia. Some of the more recently developed antipsychotic drugs also have been found to reduce bipolar symptoms (Perlis et al., 2006).

The best evidence that these drugs work comes from meta-analyses of studies that compared the experiences of people receiving a mood stabilizer to those of people receiving a placebo drug. One such meta-analysis has documented the effectiveness of lithium, which was particularly effective in reducing manic episodes (Geddes et al., 2004). Another indicates that some antipsychotics can reduce bipolar symptoms particularly rapidly (Cruz et al., 2010).

Major depression and bipolar disorder are not the only depressive disorders. In postpartum depression, which affects 10 to 15% of women who give birth (Pearlstein et al., 2009), women experience symptoms akin to those of major depression beginning within a few weeks of childbirth (NIHM, 2011). In seasonal affective disorder, individuals tend to experience depressed mood during late autumn and winter, periods when there is less sunlight (Rosenthal, 2009). Light therapy can help sufferers. Exposure to bright light for about half an hour a day relieves symptoms, an effect that may be due to the influence of intense light on neurotransmitters in the brain (Virk et al., 2009).

Want to brighten your mood? Exposure to bright light can help relieve symptoms of seasonal affective disorder, in which individuals experience depressed mood during late autumn and winter.

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WHAT DO YOU KNOW?…

Question 13

Which of the following statements are true of bipolar disorder?

  • WXREAxZac3OSycd/jqzN3MfIuoasSs7cQVTB+iYI8RXiKug00a9+3eQ7+7b3flp3YcgBo8bZGULj3N1JYk0j3xUggcP53tx+ZWqeDHFqrLMC4ldlS9b23Hcb8CW8F7b+ARJ3GpkVHsbDl1r1kCdTIE6LvPk18fhKxOCZid8IL/gOP65LneLTOH+REBHoMABi4wIxr4tZxw9eFShaAD3gyAY/uMw=
  • KG7REIitCw1YQRztqWVWe1NrzKHee3tFDAfobUQ2J58IcpdU40Y9RElVZk8vC9yf/YQdSE4Xo4pq+Q1gxAJjismsTbuTv5gCveRDkpTapVGqm3xkCqkUNzLDA4ikcKOZH+KwhkgZC9Kzp7lCJS6nMYY9AP4YQxOnkUBzk6MOmPKIM5z0yrAUYJlJ/X5LpOFJSWj1AxQLl9R5RWcLfqRTdJBXR0V9vBqCSClmb3W2SyAxmqprG2H0+vknydzOxO4N7nIHsFSjuiuuRfaXVT4MLQ==
  • 72sXCsYMYNOSvUrfseSS4YHvv86iwcdbIrB84togi0QVxBBxAUAXm+xfe0yuNIpKvCPYcuDq0hD2LJ7ei0Gg/W6goOYc4kdelt3pd5K3odU4p0CBqilLdx+4UCJdeOZ3BgTESdNwqi+5lj3ULbD3EZwjvwrmA89eiPYm7bss911Lgx1Dgk+SZGVFWEb9b2qK
  • UreLVLf/2p7cK081OjwjpRzNPPG1POdlG9ETpJrvWoplKRTd8Wg7IxDhohcSRmNJQYT83BGngfI+rgMNt+/O0uJOckK1tZQxI3JKvNwdVCPvWBDJR5y4P4UofC9gYs9br8qVwKfjB/6b3RH2/Y8TY4Cctohajv89Eu3Trn9xQmM+G4EVS9bEG4Xq/8+vnayVNsHTdGDNkphW4yOjDoOQOI7MqxP2o9FbnELUnXmI9j3vMTCWCVCA5s3zuZaf1cPl4VmiYcgbA2tGgCYf