Mitotic recombination. The most common path of mitotic recombination is SDSA (left). After strand invasion and strand extension, the invading strand is displaced. It can then anneal with its complement on the other side of the original double-strand break. Replication, nucleolytic trimming as needed, and ligation complete the process. Crossovers occur in recombination events in the DSBR pathway (right). Rad52 protein may be involved in initiation of the second strand invasion that leads to the double Holliday intermediate.