Two paths for completing double-strand break repair. (a) In the SDSA pathway, the invading strands dissociate and anneal to each other. Further replication and ligation complete the process. (b) In the DSBR pathway, the two Holliday intermediates are cleaved by Holliday intermediate resolvases (see Section 13.2). Resolution of the Holliday intermediates can yield two different results with respect to the DNA flanking the repair site, as described in the text.