FIGURE 1 Hepatitis C virus replication is reduced in the absence of miR-122 RNA in the host cell. (a) When miR-122 was expressed in a cell harboring HCV, Northern blots showed production of HCV RNAs (lane 1). When an RNA complementary to miR-122 was also present, to sequester miR-122, HCV RNA production declined markedly (lane 2). Northern blots for a housekeeping gene that encodes actin, used as a control, are also shown. (b) Quantification of the results of the same experiments.