A protein structure designed by computation. (a) The structure of a zinc-binding domain from a DNA-binding protein (Zif268). (b) The predicted structure of the FSD1 sequence, derived entirely by computation. (c) The NMR structure of FSD1. (d) Superimposition of the Zif268 zinc-binding domain (red) and FSD1 (blue). Only residues 3 through 26 are shown.